PMID- 12809616
OWN - NLM
STAT- MEDLINE
DCOM- 20030821
LR  - 20191107
IS  - 1569-9048 (Print)
IS  - 1569-9048 (Linking)
VI  - 135
IP  - 2-3
DP  - 2003 May 30
TI  - Neuronal growth factors and development of respiratory control.
PG  - 155-65
AB  - Neurotrophic molecules, released by neurons and neural target tissues, play a 
      pivotal role in regulating neuronal development and plasticity. This article 
      reviews recent work demonstrating the pivotal role of two such molecules, 
      brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic 
      factor (GDNF), in the growth and maturation of respiratory neurons and the 
      expression of normal ventilatory behavior. Although BDNF and GDNF are 
      structurally dissimilar and signal through wholly distinct receptors, they are 
      both required for development of peripheral chemoafferent neurons that provide 
      hypoxic drive to the brainstem respiratory network. Studies of genetically 
      engineered mice carrying targeted deletions in the genes encoding BDNF and GDNF, 
      as well as genetic linkage analysis in humans, indicate that these trophic 
      molecules may be candidate genes for human developmental disorders of breathing.
FAU - Katz, David M
AU  - Katz DM
AD  - Department of Neurosciences, Case Western Reserve University School of Medicine, 
      10900 Euclid Avenue, Cleveland, OH 44106-4975, USA. dmk4@po.cwru.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Respir Physiol Neurobiol
JT  - Respiratory physiology & neurobiology
JID - 101140022
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gdnf protein, mouse)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Mice
MH  - Mice, Knockout
MH  - Mutation
MH  - Nerve Growth Factors/genetics/*physiology
MH  - Rats
MH  - Respiration/genetics
MH  - Respiration Disorders/etiology/genetics
MH  - Respiratory Physiological Phenomena
MH  - Respiratory System/*growth & development
MH  - Signal Transduction/genetics/physiology
RF  - 53
EDAT- 2003/06/18 05:00
MHDA- 2003/08/22 05:00
CRDT- 2003/06/18 05:00
PHST- 2003/06/18 05:00 [pubmed]
PHST- 2003/08/22 05:00 [medline]
PHST- 2003/06/18 05:00 [entrez]
AID - S156990480300034X [pii]
AID - 10.1016/s1569-9048(03)00034-x [doi]
PST - ppublish
SO  - Respir Physiol Neurobiol. 2003 May 30;135(2-3):155-65. doi: 
      10.1016/s1569-9048(03)00034-x.