PMID- 12809778
OWN - NLM
STAT- MEDLINE
DCOM- 20040421
LR  - 20191210
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 24
IP  - 20
DP  - 2003 Sep
TI  - Synthesis, permeability and biocompatibility of tricomponent membranes containing 
      polyethylene glycol, polydimethylsiloxane and polypentamethylcyclopentasiloxane 
      domains.
PG  - 3493-503
AB  - The synthesis of "smart" tricomponent amphiphilic membranes containing 
      poly(ethylene glycol) (PEG), polydimethylsiloxane (PDMS) and 
      polypentamethylcyclopentasiloxane (PD(5)) domains is described. Contact angle 
      hysteresis indicates that in air, the surfaces of such PEG/PD(5)/PDMS membranes 
      are enriched by the hydrophobic components, PDMS and PD(5), while in water, the 
      surfaces are rich in the hydrophilic PEG. The oxygen permeability of a series of 
      membranes with varying M(c,hydrophilic) (M(n,PEG)=4600, 10,000 and 20,000 g/mol) 
      and varying PEG/PD(5)/PDMS compositions was studied. Oxygen permeability 
      increased with the amount of PDMS in the membrane. The molecular weight cut-off 
      (MWCO) ranges and permeability coefficients of insulin through a series of 
      PEG/PD(5)/PDMS(=29/14/57) membranes with varying M(c,hydrophilic) were 
      determined. Insulin permeability is directly related to M(c,hydrophilic) of the 
      membrane. MWCO studies show that the membranes are semipermeable to, i.e., allow 
      the transport of smaller proteins such as insulin (M(n)=5733 g/mol, R(s)=1.34 nm) 
      and cytochrome c (M(n)=12,400 g/mol, R(s)=1.63 nm), but are barriers to larger 
      proteins such as albumin (M(n)=66,000 g/mol, R(s)=3.62 nm). Implantation of 
      representative membranes in rats showed them to be biocompatible. According to 
      these studies, PEG/PD(5)/PDMS membranes may be suitable for biological 
      applications, e.g., immunoisolation of cells.
FAU - Kurian, P
AU  - Kurian P
AD  - Institute of Polymer Science, The University of Akron, Akron, OH 44325-3909, USA.
FAU - Kasibhatla, B
AU  - Kasibhatla B
FAU - Daum, J
AU  - Daum J
FAU - Burns, C A
AU  - Burns CA
FAU - Moosa, M
AU  - Moosa M
FAU - Rosenthal, K S
AU  - Rosenthal KS
FAU - Kennedy, J P
AU  - Kennedy JP
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Biocompatible Materials)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Insulin)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Silicones)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 63148-62-9 (baysilon)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry/*metabolism
MH  - Diffusion
MH  - Dimethylpolysiloxanes/chemistry/*metabolism
MH  - Insulin/metabolism
MH  - Male
MH  - *Membranes, Artificial
MH  - Molecular Structure
MH  - Molecular Weight
MH  - Permeability
MH  - Polyethylene Glycols/chemistry/*metabolism
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Silicones/chemistry/*metabolism
EDAT- 2003/06/18 05:00
MHDA- 2004/04/22 05:00
CRDT- 2003/06/18 05:00
PHST- 2003/06/18 05:00 [pubmed]
PHST- 2004/04/22 05:00 [medline]
PHST- 2003/06/18 05:00 [entrez]
AID - S0142961203001893 [pii]
AID - 10.1016/s0142-9612(03)00189-3 [doi]
PST - ppublish
SO  - Biomaterials. 2003 Sep;24(20):3493-503. doi: 10.1016/s0142-9612(03)00189-3.