PMID- 12809986
OWN - NLM
STAT- MEDLINE
DCOM- 20030710
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 345
IP  - 1
DP  - 2003 Jul 10
TI  - Unimodal circadian rhythm in the suprachiasmatic nucleus of behaviorally 
      splitting mice.
PG  - 49-52
AB  - CS mice exhibit rhythm splitting in constant darkness (DD). To examine the 
      anatomical and physiological bases of this phenomenon, mouse Period1 
      (mPer1)-driven green fluorescent protein (GFP) mice with rhythm splitting were 
      produced by crossing CS and mPer1::GFP mice. GFP expression in the 
      suprachiasmatic nucleus (SCN) slices showed a clear unimodal rhythm with the 
      highest level at circadian time (CT) 8 or CT12 in splitting and non-splitting GFP 
      mice under DD and no essential differences in the pattern of GFP expression were 
      found between these mice. Moreover, there were no significant differences in the 
      degree of symmetry in the paired rostral, central and caudal SCN between 
      splitting and non-splitting mice. These results indicate that behavioral rhythm 
      splitting in CS mice does not reflect the pattern of clock gene expression in the 
      SCN.
FAU - Watanabe, Tsuyoshi
AU  - Watanabe T
AD  - Division of Biomodeling, Graduate school of Bioagricultural Sciences, Nagoya 
      University, Japan.
FAU - Yoshimura, Takashi
AU  - Yoshimura T
FAU - McMahon, Douglas G
AU  - McMahon DG
FAU - Ebihara, Shizufumi
AU  - Ebihara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Luminescent Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Per1 protein, mouse)
RN  - 0 (Period Circadian Proteins)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Animals
MH  - Cell Cycle Proteins
MH  - *Circadian Rhythm
MH  - Crosses, Genetic
MH  - Darkness
MH  - Green Fluorescent Proteins
MH  - Luminescent Proteins/genetics/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - *Motor Activity
MH  - Nuclear Proteins/genetics
MH  - Period Circadian Proteins
MH  - Promoter Regions, Genetic
MH  - Suprachiasmatic Nucleus/anatomy & histology/metabolism/*physiology
EDAT- 2003/06/18 05:00
MHDA- 2003/07/11 05:00
CRDT- 2003/06/18 05:00
PHST- 2003/06/18 05:00 [pubmed]
PHST- 2003/07/11 05:00 [medline]
PHST- 2003/06/18 05:00 [entrez]
AID - S0304394003004841 [pii]
AID - 10.1016/s0304-3940(03)00484-1 [doi]
PST - ppublish
SO  - Neurosci Lett. 2003 Jul 10;345(1):49-52. doi: 10.1016/s0304-3940(03)00484-1.