PMID- 12810248
OWN - NLM
STAT- MEDLINE
DCOM- 20030728
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 144
IP  - 1
DP  - 2003 Jul 1
TI  - Deletion of chromosome 15 represents a rare but recurrent chromosomal abnormality 
      in myelocytic malignancies.
PG  - 1-5
AB  - We report on three cases with myelocytic malignancies cytogenetically 
      characterized by a deletion of chromosome 15 occurring as the sole cytogenetic 
      aberration. The deletions were defined as del(15) (q12q21) (two cases) and 
      del(15)(q11q21) (one case). Cytogenetic analysis was supplemented by fluorescence 
      in situ hybridization (FISH) using a chromosome 15 specific whole chromosome 
      painting probe and probes hybridizing to the UBE3A gene on 15q11~q13, the PML 
      gene on 15q22, and the telomeric region of 15q. Hereby, an interstitial deletion 
      of 15q including UBE3A, but not PML and the telomeric region of 15q could be 
      demonstrated. Two of our patients were diagnosed as acute myelocytic leukemia 
      (AML) with bone marrow dysplasia classified as AML-M6 and AML-M4, respectively, 
      according to the French-American-British classification; the third patient 
      suffered from a chronic myelomonocytic leukemia (CMMoL). In two cases, the 
      aberration was found at the time of primary diagnosis, whereas the third case 
      showed the del(15) only during relapse of leukemia. Both cases with acute 
      leukemia did not adequately respond to intensive chemotherapeutic treatment and 
      died 13 and 11 months, respectively, after primary diagnosis. Our findings and 
      the data of five previously published cases with an isolated del(15) indicate 
      that: 1) del(15) represents a rare but recurrent abnormality in myelocytic 
      hemopathies; 2) in our cases, del(15) was interstitial and included the region 
      15q11~q13/UBE3A, but not 15q22/PML and the telomeric region of 15q as shown by 
      FISH; 3) del(15) occurs frequently in disorders with myelodysplastic or 
      myeloproliferative features and may therefore affect early hematopoietic 
      progenitor cells; and 4) del(15) may occur during disease progression and is 
      often associated with an unfavorable prognosis.
FAU - Dierlamm, Judith
AU  - Dierlamm J
AD  - Departments of Oncology and Hematology, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany. judith_dierlamm@yahoo.de
FAU - Schilling, Georgia
AU  - Schilling G
FAU - Michaux, Lucienne
AU  - Michaux L
FAU - Hinz, Kristina
AU  - Hinz K
FAU - Murga Penas, Eva Maria
AU  - Murga Penas EM
FAU - Seeger, Doris
AU  - Seeger D
FAU - Hagemeijer, Anne
AU  - Hagemeijer A
FAU - Hossfeld, Dieter Kurt
AU  - Hossfeld DK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 15
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
RF  - 7
EDAT- 2003/06/18 05:00
MHDA- 2003/07/29 05:00
CRDT- 2003/06/18 05:00
PHST- 2003/06/18 05:00 [pubmed]
PHST- 2003/07/29 05:00 [medline]
PHST- 2003/06/18 05:00 [entrez]
AID - S0165460802008634 [pii]
AID - 10.1016/s0165-4608(02)00863-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Jul 1;144(1):1-5. doi: 
      10.1016/s0165-4608(02)00863-4.