PMID- 12810252
OWN - NLM
STAT- MEDLINE
DCOM- 20030728
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 144
IP  - 1
DP  - 2003 Jul 1
TI  - Tetrasomy 6 and 6q14 deletion are associated with better survival in 
      hepatocellular carcinomas. a fluorescence in situ hybridization study of 77 
      cases.
PG  - 23-30
AB  - We previously described frequent 6q14 deletion and polysomy 6 in 25 
      hepatocellular carcinomas (HCC) by fluorescence in situ hybridization (FISH). A 
      more favorable prognosis was noted in patients with 6q14 deletions. To confirm 
      this clinical association, a two-colored FISH study was carried out on 77 HCC 
      using a combination of a yeast artificial chromosome probe (813_E_12) of the 6q14 
      region and a chromosome 6 centromeric probe (D6Z1) for simultaneous evaluation of 
      the copy number change and chromosome arm deletion. The 77 HCC were divided into 
      four groups according to the copy number of the centromeric signal: 26 with HCC 
      (33.7%) were disomy for chromosome 6, 9 with HCC (11.7%) were trisomy, 29 with 
      HCC (37.6%) were tetrasomy, and 13 with HCC (17%) were classified as hypersomy 
      with presence of one major clone (>7%) of pentasomy or hexasomy of chromosome 6. 
      Allelic loss at 6q14 was found in 40 with HCC (52%). The distribution of sex, 
      age, stage, tumor size, tumor grade, and viral markers in each group showed no 
      significant differences. An association with cirrhosis, however, was 
      significantly lower in the hypersomy group (P = 0.001). The tetrasomy group had 
      the best survival. An interaction between 6q14 deletion and numerical change of 
      chromosome 6 on patients' survival were also noted. For patients with 6q14 
      deletion, both disomy and tetrasomy groups had significantly better survival 
      rates than trisomy and hypersomy groups. In contrast, no differences in survival 
      rates could be observed among these four groups for patients without the 6q14 
      deletion. The association with more favorable prognosis shown in this study 
      indicates that tetrasomy 6 and 6q14 deletion may play an important role in the 
      tumorigenesis of hepatocellular carcinoma and is worthy of further investigation.
FAU - Huang, Shiu Feng
AU  - Huang SF
AD  - Department of Pathology, Chang-Gung Memorial Hospital, Chang-Gung University 
      School of Medicine, 333, Tao Yuan, Taiwan. sfhuang@adm.cgmh.org.tw
FAU - Hsu, Hey Chi
AU  - Hsu HC
FAU - Chen, Jeng Chang
AU  - Chen JC
FAU - Chie, Wei Chu
AU  - Chie WC
FAU - Lai, Polin
AU  - Lai P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Carcinoma, Hepatocellular/genetics/*mortality
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 6
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Liver Neoplasms/genetics/*mortality
MH  - *Survival Rate
EDAT- 2003/06/18 05:00
MHDA- 2003/07/29 05:00
CRDT- 2003/06/18 05:00
PHST- 2003/06/18 05:00 [pubmed]
PHST- 2003/07/29 05:00 [medline]
PHST- 2003/06/18 05:00 [entrez]
AID - S0165460802008609 [pii]
AID - 10.1016/s0165-4608(02)00860-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Jul 1;144(1):23-30. doi: 
      10.1016/s0165-4608(02)00860-9.