PMID- 12810347
OWN - NLM
STAT- MEDLINE
DCOM- 20031209
LR  - 20191107
IS  - 1059-1311 (Print)
IS  - 1059-1311 (Linking)
VI  - 12
IP  - 5
DP  - 2003 Jul
TI  - Nonconvulsive status epilepticus due to a de novo contralateral focus during 
      tiagabine adjunctive therapy.
PG  - 319-22
AB  - We describe a 30-year-old woman with an infantile-onset epilepsy due to a left 
      temporal gliotic area who developed a nonconvulsive status epilepticus (NCSE) 
      during tiagabine (TGB) adjunctive therapy. The ictal EEG recording showed a de 
      novo right temporal focus not previously evident. After the i.v. administration 
      of 4 mg lorazepam, the NCSE episode rapidly resolved and her usual left temporal 
      EEG abnormalities reappeared. To our knowledge this is the first case of 
      paradoxical seizure exacerbation associated with TGB therapy in which the 
      clinical and EEG features are congruous with a new contralateral focus.
FAU - Imperiale, Daniele
AU  - Imperiale D
AD  - Neurologic Unit-Maria Vittoria Hospital, Torino, Italy. imperid@inwind.it
FAU - Pignatta, Piero
AU  - Pignatta P
FAU - Cerrato, Paolo
AU  - Cerrato P
FAU - Montalenti, Elisa
AU  - Montalenti E
FAU - Ravetti, Carlo
AU  - Ravetti C
FAU - Benna, Paolo
AU  - Benna P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Anticonvulsants)
RN  - 0 (Nipecotic Acids)
RN  - Z80I64HMNP (Tiagabine)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/administration & dosage/*adverse effects
MH  - Dominance, Cerebral/*drug effects
MH  - Drug Therapy, Combination
MH  - Electroencephalography/drug effects
MH  - Epilepsy, Complex Partial/*drug therapy
MH  - Female
MH  - Gliosis/complications
MH  - Humans
MH  - Nipecotic Acids/administration & dosage/*adverse effects
MH  - Parietal Lobe/drug effects
MH  - Status Epilepticus/*chemically induced/diagnosis
MH  - Temporal Lobe/drug effects
MH  - Tiagabine
EDAT- 2003/06/18 05:00
MHDA- 2003/12/10 05:00
CRDT- 2003/06/18 05:00
PHST- 2003/06/18 05:00 [pubmed]
PHST- 2003/12/10 05:00 [medline]
PHST- 2003/06/18 05:00 [entrez]
AID - S1059131102002935 [pii]
AID - 10.1016/s1059-1311(02)00293-5 [doi]
PST - ppublish
SO  - Seizure. 2003 Jul;12(5):319-22. doi: 10.1016/s1059-1311(02)00293-5.