PMID- 12811311
OWN - NLM
STAT- MEDLINE
DCOM- 20031006
LR  - 20091016
IS  - 0954-691X (Print)
IS  - 0954-691X (Linking)
VI  - 15
IP  - 7
DP  - 2003 Jul
TI  - Immunoglobulin E production in chronic pancreatitis.
PG  - 801-7
AB  - OBJECTIVES: Serum immunoglobulin E (IgE) was investigated in patients with 
      chronic pancreatitis in order to elucidate possible disease mechanisms linking 
      pancreatitis, adverse reaction to foods and allergy. DESIGN AND METHODS: Serum 
      IgE was analysed in 86 non-atopic patients with advanced chronic pancreatitis and 
      54 non-atopic controls. IgE detection was performed by enzyme-linked 
      immunofluorescence. RESULTS: Mean IgE levels (+/- standard error of mean) in 
      chronic pancreatitis patients (286.1+/-49 kU/l) were found to be significantly 
      elevated compared to controls (67.7+/-11 kU/l; P<0.0001). Normal IgE levels (<100 
      kU/l) were present in 40/54 control patients (74.1%), but only 39/86 pancreatitis 
      patients (45.3%). Of the patients with chronic pancreatitis, 47/86 (54.6%) had 
      clearly elevated IgE levels of >100 kU/l and their IgE values did not show a 
      Gaussian distribution. However, nine-fold higher IgE levels were found in chronic 
      pancreatitis patients with alcohol consumption of >25 g/day and exocrine 
      insufficiency (915.5+/-240 kU/l) than in pancreatitis patients with normal 
      exocrine function and no alcohol consumption (103.4+/-43 kU/l; P<0.001). 
      Moreover, acute episodes of chronic pancreatitis were found to increase serum IgE 
      levels. CONCLUSIONS: In patients with chronic pancreatitis, serum IgE production 
      is markedly enhanced, especially during acute inflammatory episodes or when 
      alcohol is consumed. Since abstinence from alcohol and pancreatic enzyme 
      substitution are associated with clearly lower IgE levels, it may be concluded 
      that pancreatic insufficiency with reduced nutrient digestion and alcohol 
      consumption stimulate IgE production. This finding gives rise to the speculation 
      that, apart from pancreatic inflammation, cross-linking of IgE with alimentary or 
      other antigens might be involved in the pathophysiology of a sub-population of 
      patients with chronic pancreatitis and manifest pancreatic insufficiency.
FAU - Raithel, Martin
AU  - Raithel M
AD  - Functional Tissue Diagnostics, Department of Medicine I, University Erlangen 
      Nuremberg, Germany. Martin.Raithel@med1.imed.uni-erlangen.de
FAU - Dormann, Harald
AU  - Dormann H
FAU - Harsch, Igor A
AU  - Harsch IA
FAU - Winterkamp, Sandra
AU  - Winterkamp S
FAU - Weidenhiller, Michael
AU  - Weidenhiller M
FAU - Fischer, Bernhard
AU  - Fischer B
FAU - Hahn, Eckhart Georg
AU  - Hahn EG
FAU - Schneider, Thomas
AU  - Schneider T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (Gastrointestinal Agents)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8049-47-6 (Pancreatin)
RN  - EC 3.4.21.36 (Pancreatic Elastase)
SB  - IM
CIN - Eur J Gastroenterol Hepatol. 2004 Aug;16(8):809-10; author reply 810-1. PMID: 
      15256985
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking/immunology
MH  - Chronic Disease
MH  - Feces/enzymology
MH  - Female
MH  - Gastrointestinal Agents/therapeutic use
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Elastase/metabolism
MH  - Pancreatin/therapeutic use
MH  - Pancreatitis/drug therapy/enzymology/*immunology
EDAT- 2003/06/18 05:00
MHDA- 2003/10/08 05:00
CRDT- 2003/06/18 05:00
PHST- 2003/06/18 05:00 [pubmed]
PHST- 2003/10/08 05:00 [medline]
PHST- 2003/06/18 05:00 [entrez]
AID - 10.1097/01.meg.0000059143.68845.af [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2003 Jul;15(7):801-7. doi: 
      10.1097/01.meg.0000059143.68845.af.