PMID- 12811505
OWN - NLM
STAT- MEDLINE
DCOM- 20040810
LR  - 20181113
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 24
IP  - 2
DP  - 2004 Mar
TI  - Human leukocyte antigen distribution in Israeli patients with psoriatic 
      arthritis.
PG  - 93-7
AB  - OBJECTIVES: This study was designed to investigate the distribution of human 
      leukocyte antigen (HLA) classes I and II in a group of Israeli Jewish patients 
      with psoriatic arthritis (PsA) and identify HLA markers related to disease 
      manifestation in PsA. PATIENTS AND METHODS: Human leukocyte antigens class I and 
      class II (both serologically and from oligotyping) were tested in a group of 50 
      consecutive patients with PsA, 32 with skin psoriasis (PSO), and 255 healthy 
      persons. Data on age, gender, disease duration, and pattern of rheumatological 
      manifestations-oligoarthritis, polyarthritis, spinal involvement, involvement of 
      distal interphalangeal joints (DIPs), and enthesitis-were registered. RESULTS: 
      Human leukocyte antigens A3, B13, and B38 alleles were found to be significantly 
      prevalent in PsA compared with PSO patients and healthy controls. HLA-B27 was 
      found in only two out of 50 patients with PsA. Patients with PSO and PsA had 
      significantly increased incidence of HLA-DRB0101 and -DRB0301, while the 
      frequency of HLA-DRB0403 was significantly higher among patients with PsA of 
      Ashkenazi origin. We found a statistically significant association between DIP 
      involvement and the presence of HLA-A26 and -B38, while HLA-DRB0301 was related 
      to spinal involvement. CONCLUSIONS: Psoriatic arthritis in Israeli patients seems 
      to be associated with the presence of HLA-A3, -B13, -B38, -DRB0101, and -DRB0301. 
      HLA-B27 was not a marker of PsA in this cohort of patients, including patients 
      with psoriatic spondyloarthropathy.
FAU - Elkayam, Ori
AU  - Elkayam O
AD  - Department of Rheumatology, Sourasky Medical Center, Tel Aviv, Israel. 
      oribe14@netvision.net.il
FAU - Segal, Refael
AU  - Segal R
FAU - Caspi, Dan
AU  - Caspi D
LA  - eng
PT  - Journal Article
DEP - 20030617
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Psoriatic/blood/ethnology/*immunology
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Female
MH  - HLA Antigens/blood/*immunology
MH  - Humans
MH  - Israel
MH  - Jews/ethnology
MH  - Male
MH  - Middle Aged
EDAT- 2003/06/18 05:00
MHDA- 2004/08/11 05:00
CRDT- 2003/06/18 05:00
PHST- 2002/10/17 00:00 [received]
PHST- 2003/03/20 00:00 [accepted]
PHST- 2003/06/18 05:00 [pubmed]
PHST- 2004/08/11 05:00 [medline]
PHST- 2003/06/18 05:00 [entrez]
AID - 10.1007/s00296-003-0325-0 [doi]
PST - ppublish
SO  - Rheumatol Int. 2004 Mar;24(2):93-7. doi: 10.1007/s00296-003-0325-0. Epub 2003 Jun 
      17.