PMID- 1281242
OWN - NLM
STAT- MEDLINE
DCOM- 19930112
LR  - 20200928
IS  - 0446-6586 (Print)
IS  - 0446-6586 (Linking)
VI  - 89
IP  - 11
DP  - 1992 Nov
TI  - [Hepatic protein synthesis and cytokines in obstructive jaundice].
PG  - 2673-81
AB  - To clarify the mechanism of the increase of hepatic protein synthesis observed in 
      the obstructive jaundiced rats, hepatocellular protein synthesis (HPS) and 
      secretory protein synthesis (SPS) were estimated in the rats with obstructive 
      jaundice and the contents of the following in the peripheral blood were 
      determined in 21 patients with obstructive jaundice before and two weeks after 
      percutaneous transhepatic biliary drainage (PTBD): interleukin-1 beta (IL-1 
      beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF alpha), endotoxin 
      (Et), acute-phase protein (APP) and negative acute-phase protein (NAPP). THE 
      RESULTS: (1) HPS and SPS were markedly increased by obstructive jaundice; (2) 
      IL-1 beta and IL-6 were significantly high and were reduced after PTBD; (3) 
      neither TNF alpha nor Et was detected; (4) APP were significantly high and failed 
      to decline after PTBD; (5) NAPP were significantly low and the contents were 
      restored to the normal levels after PTBD. These results suggest that increased 
      hepatic protein synthesis observed in the rats with obstructive jaundice 
      correspond to the increased hepatic production of APP in patients with 
      obstructive jaundice.
FAU - Kimura, F
AU  - Kimura F
AD  - Department of Surgery, Omiya Red Cross Hospital.
FAU - Miyazaki, M
AU  - Miyazaki M
FAU - Suwa, T
AU  - Suwa T
FAU - Hayashida, K
AU  - Hayashida K
FAU - Kakizaki, S
AU  - Kakizaki S
FAU - Ito, H
AU  - Ito H
FAU - Kaiho, T
AU  - Kaiho T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Shokakibyo Gakkai Zasshi
JT  - Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
JID - 2984683R
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute-Phase Proteins/*biosynthesis
MH  - Animals
MH  - Cholestasis/*metabolism
MH  - Cytokines/*biosynthesis
MH  - Humans
MH  - Liver/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Shokakibyo Gakkai Zasshi. 1992 Nov;89(11):2673-81.