PMID- 12813332
OWN - NLM
STAT- MEDLINE
DCOM- 20030717
LR  - 20220310
IS  - 0022-5282 (Print)
IS  - 0022-5282 (Linking)
VI  - 54
IP  - 6
DP  - 2003 Jun
TI  - Prevention of venous thromboembolism in the acute treatment phase after spinal 
      cord injury: a randomized, multicenter trial comparing low-dose heparin plus 
      intermittent pneumatic compression with enoxaparin.
PG  - 1116-24; discussion 1125-6
AB  - BACKGROUND: The risk of venous thromboembolism is high after spinal cord injury 
      (SCI). This prospective, multicenter study compared unfractionated heparin (UFH) 
      plus intermittent pneumatic compression (IPC) to enoxaparin alone as 
      thromboprophylaxis after SCI. METHODS: Patients with acute SCI were randomly 
      assigned to receive either UFH, 5,000 U every 8 hours, in combination with IPC or 
      enoxaparin, 30 mg every 12 hours. Outcome measures were deep vein thrombosis, 
      pulmonary embolism, and major bleeding after 2 weeks of prophylaxis. RESULTS: 
      Among 107 assessable patients, the incidence of venous thromboembolism was 63.3% 
      with UFH-IPC versus 65.5% with enoxaparin (p = 0.81). The incidence of PE was 
      18.4% with UFH-IPC versus 5.2% with enoxaparin (p = 0.03). Among all randomized 
      patients, the incidence of major bleeding was 5.3% with UFH-IPC versus 2.6% with 
      enoxaparin (p = 0.14). CONCLUSION: In the acute treatment phase after SCI, safety 
      and thromboprophylactic efficacy were generally similar with UFH-IPC and 
      enoxaparin.
CN  - Spinal Cord Injury Thromboprophylaxis Investigators
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - Bandages
MH  - Combined Modality Therapy
MH  - Enoxaparin/*administration & dosage/adverse effects
MH  - Female
MH  - Hemorrhage/chemically induced
MH  - Heparin/*administration & dosage/adverse effects
MH  - Humans
MH  - Male
MH  - Phlebography
MH  - Pressure
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Spinal Cord Injuries/*complications
MH  - Thromboembolism/diagnosis/drug therapy/etiology/*prevention & control
MH  - Treatment Outcome
MH  - Ultrasonography
EDAT- 2003/06/19 05:00
MHDA- 2003/07/18 05:00
CRDT- 2003/06/19 05:00
PHST- 2003/06/19 05:00 [pubmed]
PHST- 2003/07/18 05:00 [medline]
PHST- 2003/06/19 05:00 [entrez]
AID - 10.1097/01.TA.0000066385.10596.71 [doi]
PST - ppublish
SO  - J Trauma. 2003 Jun;54(6):1116-24; discussion 1125-6. doi: 
      10.1097/01.TA.0000066385.10596.71.