PMID- 12813912
OWN - NLM
STAT- MEDLINE
DCOM- 20030731
LR  - 20181113
IS  - 0065-7778 (Print)
IS  - 0065-7778 (Linking)
VI  - 114
DP  - 2003
TI  - E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and 
      unsuspected actions.
PG  - 67-85; discussion 85-6
AB  - Some E. coli cause diarrhea by elaborating heat-labile and heat-stable (ST) 
      enterotoxins which stimulate intestinal secretion. E. coli ST's are small 
      peptides which bind to intestinal luminal epithelial cell receptors. The ST 
      receptor, one of a family of receptor-cyclases called guanylyl cyclase C (GC-C), 
      is a membrane spanning protein containing an extracellular binding domain and 
      intracellular protein kinase and catalytic domains. The intestine synthesizes and 
      secretes homologous peptides, guanylin and uroguanylin. The kidney also 
      synthesizes uroguanylin. ST, guanylin or uroguanylin binding to GC-C results in 
      increased cGMP, phosphorylation of the CFTR Cl- channel and secretion. 
      Proguanylin and prouroguanylin circulate in blood and bind to receptors in 
      intestine, kidney, liver, brain etc. In the kidney, they stimulate the excretion 
      of Na+ and K+. Study of GC-C "knock-out" mice reveal that GC-C is important to 
      intestinal salt and water secretion, duodenal bicarbonate secretion, recovery 
      from CCl4-induced liver injury, and to intestinal polyp formation in Min mice 
      lacking GC-C.
FAU - Giannella, Ralph A
AU  - Giannella RA
AD  - Division of Digestive Diseases, University of Cincinnati College of Medicine, 231 
      Albert Sabin Way, Cincinnati, OH 45267-0595, USA. ralph.giannella@uc.edu
FAU - Mann, Elizabeth A
AU  - Mann EA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Trans Am Clin Climatol Assoc
JT  - Transactions of the American Clinical and Climatological Association
JID - 7507559
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Gastrointestinal Hormones)
RN  - 0 (Natriuretic Peptides)
RN  - 0 (Peptides)
RN  - 0 (Receptors, Peptide)
RN  - 0 (heat stable toxin (E coli))
RN  - 140653-38-9 (guanylin)
RN  - 152175-68-3 (uroguanylin)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
RN  - EC 4.6.1.2 (Receptors, Enterotoxin)
RN  - EC 4.6.1.2 (Receptors, Guanylate Cyclase-Coupled)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bacterial Toxins/genetics/*toxicity
MH  - Diarrhea/etiology/physiopathology
MH  - Enterotoxins/genetics/*toxicity
MH  - Escherichia coli/genetics/pathogenicity
MH  - Escherichia coli Infections/etiology/physiopathology
MH  - Escherichia coli Proteins
MH  - Gastrointestinal Hormones/physiology
MH  - Guanylate Cyclase/deficiency/drug effects/genetics/*physiology
MH  - Humans
MH  - Intestinal Polyps/etiology
MH  - Mice
MH  - Mice, Knockout
MH  - Models, Biological
MH  - Molecular Sequence Data
MH  - Natriuretic Peptides
MH  - Peptides/physiology
MH  - Receptors, Enterotoxin
MH  - Receptors, Guanylate Cyclase-Coupled
MH  - Receptors, Peptide/deficiency/drug effects/genetics/*physiology
PMC - PMC2194511
EDAT- 2003/06/20 05:00
MHDA- 2003/08/02 05:00
PMCR- 2003/01/01
CRDT- 2003/06/20 05:00
PHST- 2003/06/20 05:00 [pubmed]
PHST- 2003/08/02 05:00 [medline]
PHST- 2003/06/20 05:00 [entrez]
PHST- 2003/01/01 00:00 [pmc-release]
PST - ppublish
SO  - Trans Am Clin Climatol Assoc. 2003;114:67-85; discussion 85-6.