PMID- 12814660
OWN - NLM
STAT- MEDLINE
DCOM- 20030811
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 45
IP  - 1
DP  - 2003 Jul
TI  - In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex 
      by midbrain-raphe nuclei: role of 5-HT1A receptors.
PG  - 72-81
AB  - The ventral part of the medial prefrontal cortex (mPFC) plays an important role 
      in mood and cognition. This study examined the effect of the 5-HT in this region 
      by measuring the electrophysiological response of ventral mPFC neurones to 
      electrical stimulation of the dorsal and median raphe nuclei (DRN and MRN), which 
      are the source of the 5-HT input. DRN or MRN stimulation evoked a consistent, 
      short-latency, post-stimulus inhibition in the majority of ventral mPFC neurones 
      tested (DRN: 44/73 neurones; MRN: 24/31 neurones). Some neurones responded to DRN 
      or MRN stimulation with antidromic spikes indicating that they were mPFC-raphe 
      projection neurones. Both DRN- and MRN-evoked inhibitions were attenuated by 
      systemic administration of the 5-HT1A antagonist WAY 100635 (0.1 mg/kg i.v.). 
      DRN-evoked inhibition was also attenuated by iontophoretic application of WAY 
      100635 and by systemic administration of the 5-HT1A antagonist, NAD-299 (4 mg/kg 
      i.v.) but not the 5-HT2 antagonist ketanserin (4 mg/kg, i.v.). These data suggest 
      that DRN and MRN 5-HT neurones inhibit neurones in the ventral mPFC via 
      activation of 5-HT1A receptors. Some of these mPFC neurones may be part of a 
      5-HT1A receptor-controlled postsynaptic feedback loop to the DRN and MRN.
FAU - Hajos, Mihaly
AU  - Hajos M
AD  - Neurobiology, Pharmacia Corporation, 301 Henrietta Street, Kalamazoo, MI 49007, 
      USA. mihaly.hajos@pharmacia.com
FAU - Gartside, Sarah E
AU  - Gartside SE
FAU - Varga, Viktor
AU  - Varga V
FAU - Sharp, Trevor
AU  - Sharp T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Receptors, Serotonin, 5-HT1)
RN  - 0 (Serotonin Antagonists)
SB  - IM
MH  - Animals
MH  - Electric Stimulation
MH  - Electrophysiology
MH  - Mesencephalon/physiology
MH  - Neurons/*physiology
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Raphe Nuclei/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Serotonin/*physiology
MH  - Receptors, Serotonin, 5-HT1
MH  - Serotonin Antagonists/pharmacology
EDAT- 2003/06/20 05:00
MHDA- 2003/08/12 05:00
CRDT- 2003/06/20 05:00
PHST- 2003/06/20 05:00 [pubmed]
PHST- 2003/08/12 05:00 [medline]
PHST- 2003/06/20 05:00 [entrez]
AID - S0028390803001394 [pii]
AID - 10.1016/s0028-3908(03)00139-4 [doi]
PST - ppublish
SO  - Neuropharmacology. 2003 Jul;45(1):72-81. doi: 10.1016/s0028-3908(03)00139-4.