PMID- 1281520
OWN - NLM
STAT- MEDLINE
DCOM- 19930121
LR  - 20031114
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 360
IP  - 6406
DP  - 1992 Dec 24-31
TI  - Brain-derived neurotrophic factor rescues spinal motor neurons from 
      axotomy-induced cell death.
PG  - 753-5
AB  - Current ideas about the dependence of neurons on target-derived growth factors 
      were formulated on the basis of experiments involving neurons with projections to 
      the periphery. Nerve growth factor (NGF) and recently identified members of the 
      NGF family of neuronal growth factors, known as neurotrophins, are thought to 
      regulate survival of sympathetic and certain populations of sensory ganglion 
      cells during development. Far less is known about factors that regulate the 
      survival of spinal and cranial motor neurons, which also project to peripheral 
      targets. NGF has not been shown to influence motor neuron survival, and whether 
      the newly identified neurotrophins promote motor neuron survival is unknown. We 
      show here that brain-derived neurotrophic factor (BDNF) is retrogradely 
      transported by motor neurons in neonatal rats and that local application of BDNF 
      to transected sciatic nerve prevents the massive death of motor neurons that 
      normally follows axotomy in the neonatal period. These results show that BDNF has 
      survival-promoting effects on motor neurons in vivo and suggest that BDNF may 
      influence motor neuron survival during development.
FAU - Yan, Q
AU  - Yan Q
AD  - Neurobiology Program, Amgen Inc., Amgen Center, Thousand Oaks, California 91320.
FAU - Elliott, J
AU  - Elliott J
FAU - Snider, W D
AU  - Snider WD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Axonal Transport
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Death/*drug effects
MH  - Motor Neurons/*physiology/ultrastructure
MH  - Nerve Growth Factors/metabolism/*pharmacology
MH  - Nerve Tissue Proteins/metabolism/*pharmacology
MH  - Rats
MH  - Sciatic Nerve/physiology/surgery
EDAT- 1992/12/24 00:00
MHDA- 1992/12/24 00:01
CRDT- 1992/12/24 00:00
PHST- 1992/12/24 00:00 [pubmed]
PHST- 1992/12/24 00:01 [medline]
PHST- 1992/12/24 00:00 [entrez]
AID - 10.1038/360753a0 [doi]
PST - ppublish
SO  - Nature. 1992 Dec 24-31;360(6406):753-5. doi: 10.1038/360753a0.