PMID- 1281521
OWN - NLM
STAT- MEDLINE
DCOM- 19930115
LR  - 20190712
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 51
IP  - 1
DP  - 1992 Nov
TI  - Evidence for a role of the neuropeptide galanin in spatial learning.
PG  - 1-5
AB  - The neuropeptide galanin coexists with acetylcholine (ACh) in the basal forebrain 
      cholinergic neurons and modulates cholinergic activity in the forebrain. The 
      cholinergic forebrain neurons appear to play a significant role in learning and 
      memory, as suggested by a severe loss of these neurons in Alzheimer's disease. 
      The involvement of endogenous galanin in learning is demonstrated here by the use 
      of the recently synthesized high-affinity galanin antagonist M35 
      [galanin(1-13)-bradykinin(2-9) amide] (Kd = 0.1 nM). Intracerebroventricular 
      (i.c.v.) administration of M35 (6 but not 3 nmol) produced a significant (P < 
      0.025) facilitation of acquisition in a spatial learning test (Morris swim maze) 
      without any increase in swim speed. Thus, M35 (6 nmol) shortened the escape 
      latency, reduced the number of failures to reach the platform, and shortened the 
      path length to reach the hidden platform. M35 (3 and 6 nmol) tended to enhance 
      retention performance seven days after the last training session. Receptor 
      autoradiographic studies on the distribution of [125I]M35 following i.c.v. 
      administration show that it binds preferentially in the periventricular regions 
      including the hippocampus. These results suggest that galanin may modulate 
      spatial learning and memory and that galanin antagonists may provide a new 
      principle in the treatment of Alzheimer's disease.
FAU - Ogren, S O
AU  - Ogren SO
FAU - Hokfelt, T
AU  - Hokfelt T
FAU - Kask, K
AU  - Kask K
FAU - Langel, U
AU  - Langel U
FAU - Bartfai, T
AU  - Bartfai T
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Neuropeptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides)
RN  - 0 (Receptors, Galanin)
RN  - 0 (Receptors, Gastrointestinal Hormone)
RN  - 142846-71-7 (galanin-(1-13)-bradykinin-(2-9)-amide)
RN  - 88813-36-9 (Galanin)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding, Competitive
MH  - Bradykinin/administration & dosage/*analogs & derivatives/pharmacology
MH  - Brain/*metabolism
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Galanin
MH  - Injections, Intraventricular
MH  - Kinetics
MH  - Learning/*drug effects
MH  - Memory/drug effects
MH  - Molecular Sequence Data
MH  - Neuropeptides/*pharmacology
MH  - Peptide Fragments/administration & dosage/*pharmacology
MH  - Peptides/antagonists & inhibitors/metabolism/*physiology
MH  - Rats
MH  - Receptors, Galanin
MH  - Receptors, Gastrointestinal Hormone/drug effects/*metabolism
MH  - Space Perception/drug effects
MH  - Time Factors
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - 0306-4522(92)90463-C [pii]
AID - 10.1016/0306-4522(92)90463-c [doi]
PST - ppublish
SO  - Neuroscience. 1992 Nov;51(1):1-5. doi: 10.1016/0306-4522(92)90463-c.