PMID- 12815674
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20150525
IS  - 0740-3194 (Print)
IS  - 0740-3194 (Linking)
VI  - 50
IP  - 1
DP  - 2003 Jul
TI  - Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of 
      difference-edited spectra.
PG  - 19-23
AB  - The concentration of reduced glutathione (GSH), an antioxidant, may be altered in 
      various brain diseases. MEGA-PRESS was used to edit for the (1)H NMR signal from 
      GSH in the occipital lobe of 12 normal humans. In all studies, GSH was clearly 
      detected with a spectral pattern consistent with spectra acquired from a phantom 
      containing GSH. Retention of singlet resonances in the subspectra, a key 
      advantage of this difference-editing technique, provided an unambiguous reference 
      for the offset and phase of the edited signal. Linear combination model (LCModel) 
      analysis provided an unbiased means for quantifying signal contribution from 
      edited metabolites. GSH concentration was estimated from the in vivo spectra as 
      1.3 +/- 0.2 micro mol/g (mean +/- SD, n = 12).
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Terpstra, Melissa
AU  - Terpstra M
AD  - University of Minnesota, Department of Radiology, Center for MR Research 
      Minneapolis, Minnesota.
FAU - Henry, Pierre-Gilles
AU  - Henry PG
FAU - Gruetter, Rolf
AU  - Gruetter R
LA  - eng
GR  - P41RR008079/RR/NCRR NIH HHS/United States
GR  - R01NS038672/NS/NINDS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
RN  - 0 (Protons)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adult
MH  - *Algorithms
MH  - Aspartic Acid/analogs & derivatives/analysis/chemistry/metabolism
MH  - Brain Mapping/methods
MH  - Female
MH  - Glutathione/analysis/*chemistry/*metabolism
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Occipital Lobe/*chemistry/*metabolism
MH  - Protons
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Subtraction Technique
EDAT- 2003/06/20 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/06/20 05:00
PHST- 2003/06/20 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/06/20 05:00 [entrez]
AID - 10.1002/mrm.10499 [doi]
PST - ppublish
SO  - Magn Reson Med. 2003 Jul;50(1):19-23. doi: 10.1002/mrm.10499.