PMID- 12815899
OWN - NLM
STAT- MEDLINE
DCOM- 20031128
LR  - 20140625
VI  - 17
IP  - 3
DP  - 2003 Mar
TI  - [The expression of extracellular matrix in squamous cell carcinoma of the larynx: 
      an immunohistochemical study].
PG  - 167-70
AB  - OBJECTIVE: To investigate the expression and the protective significance of 
      extracellular matrix (ECM) in laryngeal squamous cell carcinomas(LSCC). METHOD: 
      The expression and distribution of three antigens, human type IV collagen(CT IV), 
      laminin(LN) and fibronectin(FN) were immunohistochemically determined in 72 cases 
      of LSCC by using the corresponding monoclonal antibodies. The correlation of the 
      intact continuance of ECM around the tumor nest with the cell differentiation, 
      invasion mode and the regional lymph node metastasis of laryngeal squamous cell 
      carcinoma was evaluated. RESULT: In cases with poor histological differentiation, 
      the defect of ECM was more severe than that in cases with high or middle 
      histological differentiation(P < 0.01). Moreover, cases with diffuse invasion 
      revealed lower ECM expression compared with cases with better tumor-host border 
      (P < 0.01). There was a higher risk of regional lymph node metastasis among cases 
      with poor ECM expression (P < 0.01). And there was a significant association 
      between the defect of ECM and the lymph node metastasis(P < 0.01). CONCLUSION: 
      These observations indicates that testing the distribution and the expression of 
      ECM seems to be useful to evaluate the histological grading of malignancy and the 
      invasion mode of laryngeal squamous cell carcinoma and to be helpful to 
      prognosticate the frequency of regional lymph node metastasis.
FAU - Cao, Zhiwei
AU  - Cao Z
AD  - Department of Otorhinolaryngology, First Clinical Hospital, China Medical 
      University, Shenyang 110001.
FAU - Li, Xiaotian
AU  - Li X
FAU - Ren, Zhong
AU  - Ren Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Collagen Type IV)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Fibronectins)
RN  - 0 (Laminin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Collagen Type IV/biosynthesis
MH  - Extracellular Matrix Proteins/*biosynthesis
MH  - Female
MH  - Fibronectins/biosynthesis
MH  - Glottis/metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Laminin/biosynthesis
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
EDAT- 2003/06/21 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/06/21 05:00
PHST- 2003/06/21 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/06/21 05:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003 Mar;17(3):167-70.