PMID- 12816684
OWN - NLM
STAT- MEDLINE
DCOM- 20050111
LR  - 20061115
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 38
IP  - 3
DP  - 2003 Mar
TI  - [Multicenter study on screen method for gestational diabetes].
PG  - 132-5
AB  - OBJECTIVE: To investigate the feasibility of using random blood glucose to screen 
      gestational diabetes mellitus (GDM). METHOD: The random blood glucose was 
      determined in 1 038 pregnant women between 24 and 32 gestational weeks. Then 50 
      gram glucose challenge test (50 g GCT) was performed followed immediately. 
      Finally, 75 gram oral glucose tolerance test (75 g OGTT) was done without dietary 
      control for 3 days. If two values of four were abnormal, GDM was diagnosed. 
      Impaired glucose tolerance (IGT) was diagnosed if only one value was abnormal or 
      the 2nd hour value ranged from 120 to 164 mg/dl. RESULTS: (1) The determination 
      of the three steps was completed in 948 cases. Among them, 42 cases (4.4%) were 
      GDM, 372 cases (39.2%) were IGT and other 534 cases were normal. (2) In the 
      normal group, the random blood glucose were different in fasting and postprandial 
      times. No difference was found among blood glucose values determined of 50 g GCT 
      at different times except that the value of 50 g GCT 1 hour postprandial was 
      higher than the value at other times. There was no significant association 
      between random blood glucose and 50 g GCT. (3) The sensitivity and specificity 
      were 50.0% and 67.7%, when IGT was diagnosed using the cut point of 6.4 mmol/L 
      (115 mg/dl) of random blood glucose, which was similar with 51.1% of sensitivity 
      and 71.2% of specificity when using >or= 7.8 mmoL/L (140 mg/dl) as the cut point 
      of 50 g GCT. If 6.4 mmol/L (115 mg/dl) was used as the cut point in GDM group the 
      sensitivity would be 80.0%, which was much higher than that of IGT group and the 
      specificity was 61.2%. In this study, if the value of >or= 8.3 mmoL/L (150 mg/dl) 
      was used as the cut-point of 50 g GCT to screen the GDM, the sensitivity 
      decreased only 2.0% while the specificity increased more than 10.0%. CONCLUSIONS: 
      (1) The determination of random blood glucose to screen GDM couldn't replace the 
      50 g GCT, but it can be used as a complemental method and can be used repeatedly 
      at any gestational age and convenience the pregnant women and the doctors. (2) 
      The value of 8.3 mmol/L (150 mg/dl) was used as the cut-point of 50 g GCT, the 
      specificity would be increased and the requirement for OGTT would be lowered 
      markedly, which would reduce economic and psychological stress.
FAU - Wu, Lian-fang
AU  - Wu LF
AD  - Department of Bostetrics, Beijing Obstetrics and Gynecology Hospital, The Capital 
      University of Medical Sciences, Beijing 100006, China.
FAU - Liu, Dong-yan
AU  - Liu DY
FAU - Huang, Xing-hua
AU  - Huang XH
FAU - Zu, Xiu-song
AU  - Zu XS
FAU - Yang, Min
AU  - Yang M
FAU - Liu, Wei-jing
AU  - Liu WJ
FAU - Heng, Zong-hua
AU  - Heng ZH
FAU - Chi, Xin-zuo
AU  - Chi XZ
FAU - Jia, Xiao-fang
AU  - Jia XF
FAU - Hu, Min-hua
AU  - Hu MH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Diabetes, Gestational/*diagnosis
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Mass Screening/*methods
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Sensitivity and Specificity
EDAT- 2003/06/21 05:00
MHDA- 2005/01/12 09:00
CRDT- 2003/06/21 05:00
PHST- 2003/06/21 05:00 [pubmed]
PHST- 2005/01/12 09:00 [medline]
PHST- 2003/06/21 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2003 Mar;38(3):132-5.