PMID- 12818972
OWN - NLM
STAT- MEDLINE
DCOM- 20030717
LR  - 20190704
IS  - 0003-2999 (Print)
IS  - 0003-2999 (Linking)
VI  - 97
IP  - 1
DP  - 2003 Jul
TI  - The acute cerebrovascular effects of intracarotid adenosine in nonhuman primates.
PG  - 231-7, table of contents
AB  - In this study we sought to determine the acute cerebrovascular effects of 
      intracarotid adenosine by using real-time cerebral blood flow (CBF) measurements 
      in nonhuman primates. The internal carotid arteries of healthy anesthetized 
      baboons were transfemorally cannulated. Changes in CBF were continuously measured 
      at baseline and with 6 increasing doses of adenosine (0.002 to 1.5 mg/min) by use 
      of an intraparenchymal thermal diffusion (TD) probe. Each infusion lasted 5 min. 
      At baseline and at the largest dose of adenosine, CBF was also determined by the 
      intraarterial (133)Xe technique. TD measurements revealed a dose-dependent 
      increase in CBF from 32 +/- 6 mL x l00 g(-1) x min(-1) at baseline to 90 +/- 38 
      mL x l00 g(-1) x min(-1) with the largest dose of adenosine (n = 5; P < 0.0001). 
      A similar magnitude of increase in CBF was also observed with (133)Xe CBF 
      measurements. No significant increases in intracranial pressure or adverse 
      systemic hemodynamic side effects were observed during adenosine infusion. The 
      increase in CBF after adenosine lasted only for the duration of drug infusion. In 
      conclusion, the transient cerebrovascular effects of intracarotid adenosine make 
      it suitable for a trial of intraarterial vasodilator therapy and for controlled 
      manipulation of cerebrovascular resistance. IMPLICATIONS: Using a real-time 
      cerebral blood flow (CBF) measurement technique, we evaluated the acute 
      cerebrovascular effects of intracarotid adenosine in anesthetized baboons. The 
      increase in CBF lasted only for the duration of the adenosine infusion. Adenosine 
      might be a suitable drug for trial as an intraarterial vasodilator for the 
      treatment of cerebral vasospasm.
FAU - Joshi, Shailendra
AU  - Joshi S
AD  - Department of Anesthesiology, College of Physicians and Surgeons of Columbia 
      University, New York, New York 10032, USA. sj121@columbia.edu
FAU - Hartl, Roger
AU  - Hartl R
FAU - Wang, Mei
AU  - Wang M
FAU - Feng, Lei
AU  - Feng L
FAU - Hoh, Daniel
AU  - Hoh D
FAU - Sciacca, Robert R
AU  - Sciacca RR
FAU - Mangla, Sundeep
AU  - Mangla S
LA  - eng
GR  - K08 GM000698/GM/NIGMS NIH HHS/United States
GR  - K08 GM000698-03/GM/NIGMS NIH HHS/United States
GR  - K08 00698/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Anesth Analg
JT  - Anesthesia and analgesia
JID - 1310650
RN  - 0 (Vasodilator Agents)
RN  - 0 (Xenon Radioisotopes)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/administration & dosage/*pharmacology
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Carotid Artery, Internal
MH  - Cerebral Angiography
MH  - Cerebrovascular Circulation/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intra-Arterial
MH  - Intracranial Pressure/drug effects
MH  - Male
MH  - Papio
MH  - Stereotaxic Techniques
MH  - Vasodilator Agents/administration & dosage/*pharmacology
MH  - Xenon Radioisotopes
EDAT- 2003/06/24 05:00
MHDA- 2003/07/18 05:00
CRDT- 2003/06/24 05:00
PHST- 2003/06/24 05:00 [pubmed]
PHST- 2003/07/18 05:00 [medline]
PHST- 2003/06/24 05:00 [entrez]
AID - 10.1213/01.ane.0000065599.71629.91 [doi]
PST - ppublish
SO  - Anesth Analg. 2003 Jul;97(1):231-7, table of contents. doi: 
      10.1213/01.ane.0000065599.71629.91.