PMID- 12819487
OWN - NLM
STAT- MEDLINE
DCOM- 20030709
LR  - 20131121
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 75
IP  - 9 Suppl
DP  - 2003 May 15
TI  - Tolerance and chimerism.
PG  - 26S-31S
AB  - Stem-cell transplantation from human leukocyte antigen (HLA)-haploidentical 
      family members carries a high risk of rejection and graft-versus-host disease 
      (GVHD) if donor and recipient differ by more than one HLA antigen. The authors 
      have developed treatment protocols from studies in dog leukocyte 
      antigen-haploidentical dogs that prevent rejection and modify GVHD to the extent 
      that patients with aggressive hematologic neoplasia can be treated with success. 
      Principal improvements have been achieved in the use of cyclophosphamide and 
      total-body irradiation for conditioning and T-cell depletion for prevention of 
      GVHD. More recently, the combination of marrow and CD6-depleted mobilized donor 
      blood cells (MDBC) has been introduced for HLA-haploidentical transplantation on 
      the basis that CD6-depleted MDBC contain immunoregulatory cells besides stem 
      cells and natural killer cells. Clinical results are reported on 36 patients with 
      high-risk hematologic neoplasia. The results encourage the use of 
      HLA-haploidentical stem-cell transplantation at an earlier stage of the disease. 
      This method could also be of use for tolerance induction in organ 
      transplantation.
FAU - Kolb, Hans-Jochem
AU  - Kolb HJ
AD  - Clinical Cooperative Group Haematopoietic Cell Transplantation, Department of 
      Medicine III, University of Munich, Grosshadern, Munich, Germany. 
      kolb@med3.med.uni-muenchen.de
FAU - Guenther, Wolfgang
AU  - Guenther W
FAU - Gyurkocza, Boglarka
AU  - Gyurkocza B
FAU - Hoetzl, Florian
AU  - Hoetzl F
FAU - Simoes, Belinda
AU  - Simoes B
FAU - Falk, Christine
AU  - Falk C
FAU - Schleuning, Michael
AU  - Schleuning M
FAU - Ledderose, Georg
AU  - Ledderose G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Animals
MH  - Blood Group Incompatibility
MH  - Cyclophosphamide/pharmacology
MH  - Dogs
MH  - Graft vs Host Disease/prevention & control
MH  - Humans
MH  - Leukemia/surgery
MH  - Stem Cell Transplantation
MH  - *Transplantation Chimera
MH  - Transplantation Conditioning
MH  - *Transplantation Tolerance
MH  - Whole-Body Irradiation
RF  - 33
EDAT- 2003/06/24 05:00
MHDA- 2003/07/10 05:00
CRDT- 2003/06/24 05:00
PHST- 2003/06/24 05:00 [pubmed]
PHST- 2003/07/10 05:00 [medline]
PHST- 2003/06/24 05:00 [entrez]
AID - 10.1097/01.TP.0000067948.90241.82 [doi]
PST - ppublish
SO  - Transplantation. 2003 May 15;75(9 Suppl):26S-31S. doi: 
      10.1097/01.TP.0000067948.90241.82.