PMID- 12819779
OWN - NLM
STAT- MEDLINE
DCOM- 20030828
LR  - 20081121
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 9
IP  - 7
DP  - 2003 Jul
TI  - Advantage of rare HLA supertype in HIV disease progression.
PG  - 928-35
AB  - The highly polymorphic human leukocyte antigen (HLA) class I molecules help to 
      determine the specificity and repertoire of the immune response. The great 
      diversity of these antigen-binding molecules confers differential advantages in 
      responding to pathogens, but presents a major obstacle to distinguishing HLA 
      allele-specific effects. HLA class I supertypes provide a functional 
      classification for the many different HLA alleles that overlap in their 
      peptide-binding specificities. We analyzed the association of these discrete HLA 
      supertypes with HIV disease progression rates in a population of HIV-infected 
      men. We found that HLA supertypes alone and in combination conferred a strong 
      differential advantage in responding to HIV infection, independent of the 
      contribution of single HLA alleles that associate with progression of the 
      disease. The correlation of the frequency of the HLA supertypes with viral load 
      suggests that HIV adapts to the most frequent alleles in the population, 
      providing a selective advantage for those individuals who express rare alleles.
FAU - Trachtenberg, Elizabeth
AU  - Trachtenberg E
AD  - Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way 
      Oakland, California 94609, USA.
FAU - Korber, Bette
AU  - Korber B
FAU - Sollars, Cristina
AU  - Sollars C
FAU - Kepler, Thomas B
AU  - Kepler TB
FAU - Hraber, Peter T
AU  - Hraber PT
FAU - Hayes, Elizabeth
AU  - Hayes E
FAU - Funkhouser, Robert
AU  - Funkhouser R
FAU - Fugate, Michael
AU  - Fugate M
FAU - Theiler, James
AU  - Theiler J
FAU - Hsu, Yen S
AU  - Hsu YS
FAU - Kunstman, Kevin
AU  - Kunstman K
FAU - Wu, Samuel
AU  - Wu S
FAU - Phair, John
AU  - Phair J
FAU - Erlich, Henry
AU  - Erlich H
FAU - Wolinsky, Steven
AU  - Wolinsky S
LA  - eng
GR  - P30-CA79458/CA/NCI NIH HHS/United States
GR  - R01-HD37356/HD/NICHD NIH HHS/United States
GR  - U01-AI-35039/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (HLA Antigens)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Amino Acid Motifs
MH  - Blood/virology
MH  - Disease Progression
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - HIV Infections/*genetics/*immunology
MH  - HLA Antigens/*genetics/metabolism
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - RNA, Viral/metabolism
MH  - Viral Proteins/metabolism
EDAT- 2003/06/24 05:00
MHDA- 2003/08/29 05:00
CRDT- 2003/06/24 05:00
PHST- 2003/03/22 00:00 [received]
PHST- 2003/06/02 00:00 [accepted]
PHST- 2003/06/24 05:00 [pubmed]
PHST- 2003/08/29 05:00 [medline]
PHST- 2003/06/24 05:00 [entrez]
AID - nm893 [pii]
AID - 10.1038/nm893 [doi]
PST - ppublish
SO  - Nat Med. 2003 Jul;9(7):928-35. doi: 10.1038/nm893.