PMID- 1282013
OWN - NLM
STAT- MEDLINE
DCOM- 19930201
LR  - 20190907
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 106
IP  - 6
DP  - 1992 Dec
TI  - Basal forebrain neurons and memory: a biochemical, histological, and behavioral 
      study of differential vulnerability to ibotenate and quisqualate.
PG  - 909-23
AB  - The differential vulnerability of basal forebrain cells to ibotenate (IBO) or 
      quisqualate (QUIS) was investigated in rats. IBO was also coinjected with cystine 
      (CYS) or zinc (Zn). Cortical choline acetyltransferase (ChAT) and glutamate 
      decarboxylase (GAD) activity, neurotensin receptors, and high-affinity choline 
      uptake sites were quantified in conjunction with radioimmunoassays for 
      neurotensin, substance P, and somatostatin; immunocytochemistry for neurotensin-, 
      somatostatin-, Leu-enkephalin-, and ChAT-positive cells; and in situ 
      hybridization histochemistry of somatostatin, substance P, and enkephalin mRNAs. 
      Compared with the performance of controls, continuous alternation performance in 
      a T maze of IBO+Zn or IBO+CYS rats was better than that of IBO rats, whereas the 
      performance of QUIS rats was unimpaired. Of those neurotransmitter systems 
      examined, only ChAT-immunoreactive cells were vulnerable to IBO or QUIS. However, 
      cholinergic cell loss did not correlate with impaired performance.
FAU - Wenk, G L
AU  - Wenk GL
AD  - Arizona Research Laboratories, University of Arizona School of Medicine, Tucson.
FAU - Harrington, C A
AU  - Harrington CA
FAU - Tucker, D A
AU  - Tucker DA
FAU - Rance, N E
AU  - Rance NE
FAU - Walker, L C
AU  - Walker LC
LA  - eng
GR  - AG 05146/AG/NIA NIH HHS/United States
GR  - AG 09214/AG/NIA NIH HHS/United States
GR  - NS 20471/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Neuropeptides)
RN  - 0 (Receptors, Cholinergic)
RN  - 0 (Receptors, Neurotensin)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 2552-55-8 (Ibotenic Acid)
RN  - 33507-63-0 (Substance P)
RN  - 39379-15-2 (Neurotensin)
RN  - 48TCX9A1VT (Cystine)
RN  - 51110-01-1 (Somatostatin)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Attention/*drug effects/physiology
MH  - Brain Mapping
MH  - Cerebral Cortex/drug effects/physiology
MH  - Choline O-Acetyltransferase/physiology
MH  - Cholinergic Fibers/drug effects/physiology
MH  - Cystine/pharmacology
MH  - Discrimination Learning/*drug effects/physiology
MH  - Enkephalin, Leucine/physiology
MH  - Globus Pallidus/drug effects/physiology
MH  - Glutamate Decarboxylase/physiology
MH  - Ibotenic Acid/*pharmacology
MH  - Male
MH  - Mental Recall/*drug effects/physiology
MH  - Neural Pathways/drug effects/physiology
MH  - Neuropeptides/*physiology
MH  - Neurotensin/physiology
MH  - Orientation/*drug effects/physiology
MH  - Prosencephalon/*drug effects/physiology
MH  - Quisqualic Acid/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Cholinergic/drug effects/physiology
MH  - Receptors, Neurotensin
MH  - Receptors, Neurotransmitter/drug effects/physiology
MH  - Somatostatin/physiology
MH  - Substance P/physiology
MH  - Substantia Innominata/drug effects/physiology
MH  - Zinc/pharmacology
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
AID - 10.1037//0735-7044.106.6.909 [doi]
PST - ppublish
SO  - Behav Neurosci. 1992 Dec;106(6):909-23. doi: 10.1037//0735-7044.106.6.909.