PMID- 12821211
OWN - NLM
STAT- MEDLINE
DCOM- 20031118
LR  - 20190906
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 71
IP  - 1
DP  - 2003 Jul 20
TI  - Differential effects of saccharin supplementation on alcohol and water 
      consumption by Wistar rats from different sources.
PG  - 103-5
AB  - The study was aimed to elucidate whether the dissimilar effects of concurrent 
      presentation of sweet water on alcohol consumption previously reported for Wistar 
      rats from different sources remain unchanged when alcohol is also flavored with 
      0.1% saccharin. Male Wistar rats from Laboratory of Experimental Biological 
      Models (LEBM) and Krukovo animal farm (K) stocks having had 2 months free access 
      to food, tap water, and 10% alcohol were given four consecutive two-bottle 
      drinking tests: alcohol versus water, alcohol versus sweet water, sweet alcohol 
      versus water, or sweet alcohol versus sweet water. The test order was 
      quasi-random and each test lasted 4 days. In Wistar (K) rats, flavoring of either 
      water or alcohol solution increased consumption of each of the fluids and 
      decreased intake of concurrently available fluids. The elevation in water intake 
      induced by its sweetening was antagonized by flavoring of alcohol solution. In 
      Wistar (LEBM) rats, flavoring of either water or alcohol increased consumption of 
      each of the fluid, but did not change the intake of alternative fluids. The 
      stable alcohol consumption by Wistar (LEBM) rats and its suppression seen in 
      Wistar (K) rats induced by concurrent presentation of flavored water parallel the 
      patterns previously observed among P, sP, and HAD rats suggesting the existence 
      among alcohol-consuming animals of typological diversity of alcohol motivation.
FAU - Salimov, Ramiz M
AU  - Salimov RM
AD  - Institute of Pharmacology, Russian Academy of Medical Sciences, Baltyjskaya 8, 
      125315 Moscow, Russia. rsalimov@aha.ru
FAU - Maisky, Alexy I
AU  - Maisky AI
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 3K9958V90M (Ethanol)
RN  - FST467XS7D (Saccharin)
SB  - IM
MH  - *Alcohol Drinking/psychology
MH  - Animals
MH  - Drinking/*drug effects/physiology
MH  - Ethanol/*administration & dosage
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Saccharin/*administration & dosage
EDAT- 2003/06/25 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/06/25 05:00
PHST- 2003/06/25 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/06/25 05:00 [entrez]
AID - S0376871603000371 [pii]
AID - 10.1016/s0376-8716(03)00037-1 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2003 Jul 20;71(1):103-5. doi: 10.1016/s0376-8716(03)00037-1.