PMID- 12823109
OWN - NLM
STAT- MEDLINE
DCOM- 20040304
LR  - 20190823
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 58
IP  - 7
DP  - 2003 Jul
TI  - IVIG--mechanisms of action.
PG  - 543-52
AB  - Intravenous immunoglobulin (IVIG) preparations are fractionated from a plasma 
      pool of several thousand donors. IVIG contain immune antibodies and physiologic 
      autoantibodies. Immune antibodies reflect the immunologic experience of the donor 
      population. This fraction of IVIG preparations is useful for replacement therapy 
      and passive immunisation. Natural autoantibodies are able to react with the 
      immune system of the recipient of IVIG and are suggested to help to correct 
      immune deregulation. Immunomodulatory and anti-inflammatory properties are based 
      on multiple mechanisms of action which are described. These mechanisms are 
      effective concomitantly and synergistically at every occasion of use of IVIG in 
      inflammatory and autoimmune disorders.
FAU - Simon, H U
AU  - Simon HU
AD  - Department of Pharmacology, University of Bern, Switzerland; ZLB Bioplasma AG, 
      Bern, Switzerland.
FAU - Spath, P J
AU  - Spath PJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Antibodies)
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
CIN - Allergy. 2004 Oct;59(10):1124; author reply 1124. PMID: 15355473
MH  - Agammaglobulinemia/drug therapy/immunology
MH  - Antibodies/blood
MH  - Antibodies, Anti-Idiotypic/immunology
MH  - Autoimmunity/drug effects/immunology
MH  - Common Variable Immunodeficiency/drug therapy/immunology
MH  - Humans
MH  - Immune System/drug effects/immunology
MH  - Immunization, Passive
MH  - *Immunoglobulins, Intravenous/immunology/pharmacology
RF  - 98
EDAT- 2003/06/26 05:00
MHDA- 2004/03/05 05:00
CRDT- 2003/06/26 05:00
PHST- 2003/06/26 05:00 [pubmed]
PHST- 2004/03/05 05:00 [medline]
PHST- 2003/06/26 05:00 [entrez]
AID - 239 [pii]
AID - 10.1034/j.1398-9995.2003.00239.x [doi]
PST - ppublish
SO  - Allergy. 2003 Jul;58(7):543-52. doi: 10.1034/j.1398-9995.2003.00239.x.