PMID- 12823110
OWN - NLM
STAT- MEDLINE
DCOM- 20040304
LR  - 20190823
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 58
IP  - 7
DP  - 2003 Jul
TI  - Allergen-induced mediator release tests.
PG  - 553-8
AB  - The diagnosis of allergic reactions in clinical practice is based on both 
      clinical history and the determination of specific immunoglobulin E (IgE), either 
      in the serum or on skin mast cells. However, for various reasons, identification 
      of the causative factors is not possible in all the cases. Moreover, not all 
      allergies are IgE-dependent. In an attempt to find sensitive, specific and 
      cost-effective methods to investigate hypersensitivity reactions, in vitro tests 
      were developed at a very early stage. Allergen-induced mediator release assays 
      analyze the mediator released from effector cells, mainly peripheral blood cells, 
      when stimulated in vitro with serial dilutions of the putative allergens. 
      Described initially as research tools, they could well become diagnostic tests. 
      However, relatively few high quality reports have been published so far. In this 
      review, we will detail allergen-dependent histamine, tryptase, arachidonic acid 
      metabolite, e.g. cysteinyl leukotrienes and 15-hydroxyeicosatetraenoic mediator 
      release tests.
FAU - Demoly, P
AU  - Demoly P
AD  - Maladies Respiratoires - INSERM U454, CHU de Montpellier, Cedex, France.
FAU - Lebel, B
AU  - Lebel B
FAU - Arnoux, B
AU  - Arnoux B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Arachidonic Acids)
RN  - 0 (Inflammation Mediators)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Allergens/*immunology/metabolism
MH  - Animals
MH  - Antibody Specificity/immunology
MH  - Arachidonic Acids/immunology/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Cross Reactions/immunology
MH  - Histamine Release/immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/diagnosis/immunology/metabolism
MH  - Immunoglobulin E/immunology/metabolism
MH  - Immunologic Tests
MH  - Infant
MH  - Inflammation Mediators/*immunology/metabolism
MH  - Serine Endopeptidases/immunology/metabolism
MH  - Tryptases
RF  - 50
EDAT- 2003/06/26 05:00
MHDA- 2004/03/05 05:00
CRDT- 2003/06/26 05:00
PHST- 2003/06/26 05:00 [pubmed]
PHST- 2004/03/05 05:00 [medline]
PHST- 2003/06/26 05:00 [entrez]
AID - 253 [pii]
AID - 10.1034/j.1398-9995.2003.00253.x [doi]
PST - ppublish
SO  - Allergy. 2003 Jul;58(7):553-8. doi: 10.1034/j.1398-9995.2003.00253.x.