PMID- 12823116
OWN - NLM
STAT- MEDLINE
DCOM- 20040304
LR  - 20190823
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 58
IP  - 7
DP  - 2003 Jul
TI  - In utero exposure to lead and cord blood total IgE. Is there a connection?
PG  - 589-94
AB  - BACKGROUND: Lead exposure and total immunoglobulin E (IgE) have been shown to be 
      positively related in animals and humans even at lead levels below those 
      recognized as toxic. In the last decades, exposure to lead has become more 
      frequent in urban areas of industrialized as well as of developing countries 
      where IgE-mediated allergy prevalence has also increased. METHODS: We examined 
      for the first time the relationship between in utero exposure to lead and cord 
      blood total IgE in two samples of 137 and 237 mother-newborn pairs, respectively, 
      recruited in Paris. RESULTS: Cord blood IgE was positively related to hair lead 
      level at birth, providing an integrated measure of long-term exposure in utero, 
      in each cohort (Spearman's coefficient r = 0.32, P < 0.001 and r = 0.19, P < 
      0.01, respectively) and in the combined cohort (r = 0.21; P < 0.01). The 
      relationship appeared to be more pronounced in newborns of nonallergic mothers (r 
      = 0.24; P < 0.01) than in those of allergic mothers (r = 0.12). This could be due 
      to the fact that familial history of allergy, the strongest determinant of IgE 
      development, may overshadow the influence of lead on IgE in the offspring. 
      CONCLUSIONS: Our findings suggest a possible intervention of environmental 
      exposure besides genetic factors in early life development of IgE production. 
      Further studies are needed to confirm the finding.
FAU - Annesi-Maesano, I
AU  - Annesi-Maesano I
AD  - Immediate Hypersensitivity Epidemiology Department (IHED), INSERM U472: 
      Epidemiology & Biostatistics, Villejuif, France.
FAU - Pollitt, R
AU  - Pollitt R
FAU - King, G
AU  - King G
FAU - Bousquet, J
AU  - Bousquet J
FAU - Hellier, G
AU  - Hellier G
FAU - Sahuquillo, J
AU  - Sahuquillo J
FAU - Huel, G
AU  - Huel G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Biomarkers)
RN  - 2P299V784P (Lead)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Female
MH  - Fetal Blood/chemistry/*metabolism
MH  - Follow-Up Studies
MH  - Hair/metabolism
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant Welfare
MH  - Infant, Newborn
MH  - Lead/*adverse effects/*metabolism
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Maternal Welfare
MH  - Paris
MH  - Statistics as Topic
MH  - Uterus/*drug effects/*metabolism
EDAT- 2003/06/26 05:00
MHDA- 2004/03/05 05:00
CRDT- 2003/06/26 05:00
PHST- 2003/06/26 05:00 [pubmed]
PHST- 2004/03/05 05:00 [medline]
PHST- 2003/06/26 05:00 [entrez]
AID - 111 [pii]
AID - 10.1034/j.1398-9995.2003.00111.x [doi]
PST - ppublish
SO  - Allergy. 2003 Jul;58(7):589-94. doi: 10.1034/j.1398-9995.2003.00111.x.