PMID- 12823278
OWN - NLM
STAT- MEDLINE
DCOM- 20030916
LR  - 20190513
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 133
IP  - 1
DP  - 2003 Jul
TI  - Autologous apoptotic T cells interact with dendritic cells, but do not affect 
      their surface phenotype or their ability to induce recall immune responses.
PG  - 50-8
AB  - Dendritic cells (DCs) play an important role in determining immunogenicity and 
      the subsequent immune response. They may also have a role in maintaining 
      peripheral tolerance to self-antigens by initiating an immune response only in 
      the context of danger signals released from cells during stress, damage or death. 
      These signals may originate from surrounding T cells as well as from other cells. 
      Therefore, in this study the effect of autologous T cell injury on DC morphology 
      and function has been investigated. Co-incubation of apoptotic or necrotic T 
      cells with immature DCs altered their morphology towards a more mature 
      appearance, with more cells showing activation as judged by spreading and 
      formation of arborizing long processes. The apoptotic autologous T cells were 
      rarely phagocytosed by immature DCs, compared to macrophages. The DC surface 
      phenotype was not affected by the co-incubation with autologous injured T cells. 
      The ability of DCs to elicit a secondary immune response was not altered by 
      exposure to autologous injured T cells. These findings suggest that DC can 
      continue to function in T cell activation, rather than in tolerogenic mode, even 
      in the presence of large numbers of dying autologous T cells, such as may be 
      present in the aftermath of an acute antiviral response.
FAU - Newton, P J
AU  - Newton PJ
AD  - Department of Sexually Transmitted Diseases, Windeyer Institute for Medical 
      Sciences, Royal Free and University College Medical School, London, UK.
FAU - Weller, I V D
AU  - Weller IV
FAU - Katz, D R
AU  - Katz DR
FAU - Chain, B M
AU  - Chain BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
SB  - IM
MH  - Antigen Presentation
MH  - *Apoptosis
MH  - Cell Death
MH  - Coculture Techniques
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunophenotyping
MH  - Macrophages/immunology
MH  - Microscopy, Confocal
MH  - Microscopy, Phase-Contrast
MH  - Necrosis
MH  - Phagocytosis
MH  - T-Lymphocytes/*pathology
PMC - PMC1808738
EDAT- 2003/06/26 05:00
MHDA- 2003/09/17 05:00
PMCR- 2004/07/01
CRDT- 2003/06/26 05:00
PHST- 2003/06/26 05:00 [pubmed]
PHST- 2003/09/17 05:00 [medline]
PHST- 2003/06/26 05:00 [entrez]
PHST- 2004/07/01 00:00 [pmc-release]
AID - 2202 [pii]
AID - 10.1046/j.1365-2249.2003.02202.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2003 Jul;133(1):50-8. doi: 10.1046/j.1365-2249.2003.02202.x.