PMID- 12823905
OWN - NLM
STAT- MEDLINE
DCOM- 20030805
LR  - 20191210
IS  - 0894-2684 (Print)
IS  - 0894-2684 (Linking)
VI  - 16
IP  - 2
DP  - 2003 Summer
TI  - Evaluation of a new Aerodynamic Particle Sizer Spectrometer for size distribution 
      measurements of solution metered dose inhalers.
PG  - 107-19
AB  - The ability of the Model 3320 and newer Model 3321 Aerodynamic Particle Sizer 
      Spectrometer (APS) to make accurate mass-weighted size distribution measurements 
      of solution metered dose inhalers (MDIs) was evaluated. Measurements of 
      experimental HFA-134a beclomethasone dipropionate MDIs were made with both the 
      APS 3320 and APS 3321 and compared to the Andersen Cascade Impactor (ACI). The 
      mass-weighted size distribution measurements from the ACI and APS 3321 agreed 
      well but were very different than the APS 3320 measurements. Evaluation of the 
      APS 3320 size distribution measurements indicated that the presence of a few 
      erroneous particle measurements caused a gross overestimation of the mass median 
      aerodynamic diameter (MMAD) and geometric standard deviation (GSD). When a 
      previously described technique was used to eliminate erroneous particle size 
      measurements from the size distribution calculation, the MMAD and GSD from the 
      APS 3320 agreed well with those from the ACI and APS 3321. The GSD from the APS 
      3321 and the APS 3320 after a mask was applied were slightly larger than from the 
      ACI. It is believed that both APS instruments slightly underestimate the GSD 
      while the ACI slightly overestimates the GSD. Further experiments were conducted 
      using the APS 3321 to examine the influence of drug concentration and cosolvent 
      level on the size distribution of solution formulation MDIs. The MMAD was shown 
      experimentally and theoretically to be proportional to drug concentration to the 
      one-third power. Cosolvent concentration had minimal influence on MMAD over the 
      range examined. The measurements reported in this paper demonstrate that it is 
      possible to obtain accurate mass-weighted size distribution measurements with the 
      APS 3320 and APS 3321. These instruments allow for accurate size distribution 
      measurements to be made in minutes as opposed to the hours required to conduct 
      and analyze size distribution measurements from cascade impactors.
FAU - Stein, Stephen W
AU  - Stein SW
AD  - 3M Drug Delivery Systems Division, Inhalation Drug Delivery Laboratory, Saint 
      Paul, Minnesota 55144, USA. swstein@mmm.com
FAU - Myrdal, Paul B
AU  - Myrdal PB
FAU - Gabrio, Brian J
AU  - Gabrio BJ
FAU - Obereit, Derek
AU  - Obereit D
FAU - Beck, Tyler J
AU  - Beck TJ
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Aerosol Med
JT  - Journal of aerosol medicine : the official journal of the International Society 
      for Aerosols in Medicine
JID - 8809251
RN  - 0 (Aerosols)
RN  - 0 (Glucocorticoids)
RN  - KGZ1SLC28Z (Beclomethasone)
MH  - Aerosols/*administration & dosage/chemistry
MH  - Beclomethasone/*administration & dosage/chemistry
MH  - Equipment Design
MH  - Glucocorticoids/*administration & dosage/chemistry
MH  - Humans
MH  - *Nebulizers and Vaporizers
MH  - Particle Size
EDAT- 2003/06/26 05:00
MHDA- 2003/08/06 05:00
CRDT- 2003/06/26 05:00
PHST- 2003/06/26 05:00 [pubmed]
PHST- 2003/08/06 05:00 [medline]
PHST- 2003/06/26 05:00 [entrez]
AID - 10.1089/089426803321919870 [doi]
PST - ppublish
SO  - J Aerosol Med. 2003 Summer;16(2):107-19. doi: 10.1089/089426803321919870.