PMID- 12823951
OWN - NLM
STAT- MEDLINE
DCOM- 20030806
LR  - 20190916
IS  - 0165-6147 (Print)
IS  - 0165-6147 (Linking)
VI  - 24
IP  - 6
DP  - 2003 Jun
TI  - Is frequent dosing with ecstasy a risky business for dopamine-containing neurons?
PG  - 272-4
AB  - Over the past 20 years 3,4-methylenedioxymethamphetamine (MDMA; also known as 
      'ecstasy') has become a widely used recreational drug of abuse. However, studies 
      have indicated that it is neurotoxic to serotonergic nerve terminals in rats and 
      non-human primates and dopaminergic nerve terminals in mice. Recently, this tenet 
      has been questioned following a study suggesting that MDMA can cause toxicity to 
      dopamine-containing neurons in monkeys. In this article, the factors contributing 
      to this change in neurotoxic profile are discussed.
FAU - O'Shea, Esther
AU  - O'Shea E
AD  - Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de 
      Madrid, Avda Complutense s/n, 28040 Madrid, Spain. estheros@farm.ucm.es
FAU - Colado, M Isabel
AU  - Colado MI
LA  - eng
PT  - Journal Article
PL  - England
TA  - Trends Pharmacol Sci
JT  - Trends in pharmacological sciences
JID - 7906158
RN  - 0 (Receptors, Dopamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
CIN - Trends Pharmacol Sci. 2003 Jun;24(6):275. PMID: 12823952
MH  - Animals
MH  - Dopamine/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/*toxicity
MH  - Neurons/drug effects/physiology
MH  - Neurotoxicity Syndromes/etiology
MH  - Oxidative Stress/drug effects
MH  - Parkinsonian Disorders/chemically induced
MH  - Receptors, Dopamine/drug effects
MH  - Temperature
EDAT- 2003/06/26 05:00
MHDA- 2003/08/07 05:00
CRDT- 2003/06/26 05:00
PHST- 2003/06/26 05:00 [pubmed]
PHST- 2003/08/07 05:00 [medline]
PHST- 2003/06/26 05:00 [entrez]
AID - S0165614703001330 [pii]
AID - 10.1016/s0165-6147(03)00133-0 [doi]
PST - ppublish
SO  - Trends Pharmacol Sci. 2003 Jun;24(6):272-4. doi: 10.1016/s0165-6147(03)00133-0.