PMID- 12824003
OWN - NLM
STAT- MEDLINE
DCOM- 20040129
LR  - 20191107
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 21
IP  - 6
DP  - 2003 Mar 21
TI  - Excessive increase of serum interleukin 6 jeopardizes host defense against 
      multi-bacterial infection.
PG  - 295-302
AB  - Serum interleukin 6 (IL-6) is elevated among patients who have undergone surgery, 
      trauma, and thermal injury. It is well known that the greater the increase of 
      serum IL-6, the higher the incidence of post-injury morbidity and mortality is. 
      However, it has not been determined whether the physiological effects of IL-6 
      increase the rate of morbidity and mortality or if IL-6 is just a bystander that 
      only indicates the severity of the injury. To elucidate this, we planned to 
      investigate the effect of IL-6 on a multi-bacterial infection, one of the most 
      frequent post-injury complications. CDF1 male mice were administered recombinant 
      human IL-6 (hIL-6) continuously at a dose of 0, 1, or 10 microg/day. The mice 
      then underwent cecal ligation without puncture that induced slow multi-bacterial 
      infection. The survival rate of mice receiving 10 microg/day of hIL-6 was 
      significantly lower (38.5%) than the rate of those receiving 0 (83.3%) or 1 
      (92.3%) microg/day of hIL-6. The result of this study showed that only excessive 
      increases in serum IL-6, to levels that were observed among patients who 
      underwent severe injury or extensive surgery with high incidence of post-injury 
      infection, jeopardize the host's defense against bacterial infection.
FAU - Soda, Kuniyasu
AU  - Soda K
AD  - Department of Surgery, Omiya Medical Center, Jichi Medical School, 1-847 Amanuma, 
      Saitama Saitama-city 330-0834, Japan. soda@omiya.jichi.ac.jp
FAU - Kano, Yoshihiko
AU  - Kano Y
FAU - Kawakami, Masanobu
AU  - Kawakami M
FAU - Konishi, Fumio
AU  - Konishi F
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Interleukin-6)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Bacterial Infections/blood/*immunology
MH  - Body Weight/drug effects
MH  - Cecum/surgery
MH  - Epididymis/drug effects
MH  - Interleukin-6/administration & dosage/*blood/immunology
MH  - Ligation
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Organ Size/drug effects
MH  - Peritonitis/mortality
MH  - Platelet Count
MH  - Punctures
MH  - Recombinant Proteins/administration & dosage
MH  - Survival Rate
EDAT- 2003/06/26 05:00
MHDA- 2004/01/30 05:00
CRDT- 2003/06/26 05:00
PHST- 2003/06/26 05:00 [pubmed]
PHST- 2004/01/30 05:00 [medline]
PHST- 2003/06/26 05:00 [entrez]
AID - S104346660300108X [pii]
AID - 10.1016/s1043-4666(03)00108-x [doi]
PST - ppublish
SO  - Cytokine. 2003 Mar 21;21(6):295-302. doi: 10.1016/s1043-4666(03)00108-x.