PMID- 12824780
OWN - NLM
STAT- MEDLINE
DCOM- 20030916
LR  - 20190718
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 17
IP  - 10
DP  - 2003 Jul 4
TI  - Impaired growth hormone secretion correlates with visceral adiposity in highly 
      active antiretroviral treated HIV-infected adolescents.
PG  - 1435-41
AB  - BACKGROUND: HIV-infected adults with lipodystrophy, characterized by excess 
      accumulation of intra-abdominal adipose tissue (IAT), showed impaired growth 
      hormone (GH) secretion. Data are lacking in paediatric lipodystrophy with the 
      same features. METHODS: Twenty-five pubertal HIV-infected children were assessed 
      for GH response (GH-AUC(0-120 min)) to arginine + GHRH testing, insulin-like 
      growth factor-1 (IGF-1), IGF binding protein 3 (IGFBP-3), insulin, glucose, 
      cholesterol, triglycerides, free fatty acids and nitric oxide levels. Body 
      composition and IAT content were evaluated by dual-energy x-ray-absorptiometry 
      and magnetic resonance imaging. An excess accumulation of IAT was defined as a 
      value > 41 cm2. Differences between children with (V+) and without (V-) excess 
      IAT were assessed by non-parametric tests and multivariate analysis. RESULTS Ten 
      V+ (mean IAT, 82.5 cm2) and 15 V- (mean IAT, 26.8 cm2) were identified; they were 
      similar for age (13.8 versus 14.8 years), body mass index (20.2 versus 19.5 
      kg/m2), male : female ratio (3/7 versus 8/7), months on highly active 
      antiretroviral therapy (54.5 versus 55 months). V+ showed lower GH-AUC(0-120 min) 
      (16.4 versus 31.6 microg x h/l; P = 0.002), lower IGF-1 concentrations (384 
      versus 515 ng/ml; P = 0.03) and higher insulin levels (17.8 versus 10.5 
      microIU/ml; P = 0.01) than V-. V+, as compared to V-, showed lower lean mass 
      (total, P = 0.025; arms, P = 0.024; legs, P = 0.008) and higher fat mass (total, 
      P = 0.0038; arms, P = 0.028; trunk, P < 0.0001). Lipid profile and glucose, 
      IGFBP-3, nitric oxide and free fatty acids levels were similar in the two groups. 
      GH-AUC(0-120 min) correlated negatively with IAT content and insulin levels. 
      CONCLUSION: Impaired GH secretion is detectable in pubertal children with 
      increased visceral adiposity and hyperinsulinemia. GH therapy should be 
      considered in lipodystrophic HIV-infected children with excess IAT.
FAU - Vigano, Alessandra
AU  - Vigano A
AD  - L. Sacco Hospital, University of Milan, IRCCS H S. Raffaele, Milan, Italy.
FAU - Mora, Stefano
AU  - Mora S
FAU - Brambilla, Paolo
AU  - Brambilla P
FAU - Schneider, Laura
AU  - Schneider L
FAU - Merlo, Marzia
AU  - Merlo M
FAU - Monti, Lucilla D
AU  - Monti LD
FAU - Manzoni, Paola
AU  - Manzoni P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Triglycerides)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
RN  - 9034-39-3 (Growth Hormone-Releasing Hormone)
RN  - 94ZLA3W45F (Arginine)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adolescent
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Arginine
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Cholesterol/blood
MH  - Female
MH  - Growth Hormone/*metabolism
MH  - Growth Hormone-Releasing Hormone
MH  - HIV Infections/drug therapy/physiopathology
MH  - *HIV-1
MH  - HIV-Associated Lipodystrophy Syndrome/drug therapy/*physiopathology
MH  - Humans
MH  - Insulin/blood
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/analysis
MH  - Male
MH  - Multivariate Analysis
MH  - Statistics, Nonparametric
MH  - Triglycerides/blood
EDAT- 2003/06/26 05:00
MHDA- 2003/09/17 05:00
CRDT- 2003/06/26 05:00
PHST- 2003/06/26 05:00 [pubmed]
PHST- 2003/09/17 05:00 [medline]
PHST- 2003/06/26 05:00 [entrez]
AID - 10.1097/00002030-200307040-00003 [doi]
PST - ppublish
SO  - AIDS. 2003 Jul 4;17(10):1435-41. doi: 10.1097/00002030-200307040-00003.