PMID- 12825803
OWN - NLM
STAT- MEDLINE
DCOM- 20030708
LR  - 20190827
IS  - 0021-4868 (Print)
IS  - 0021-4868 (Linking)
VI  - 44
IP  - 3
DP  - 2003 May
TI  - The effects of hyperhomocysteinemia on the presence, extent, and severity of 
      coronary artery disease.
PG  - 357-68
AB  - Most cross-sectional and case-control studies indicate that an increased plasma 
      total homocysteine (tHcy) level is an independent risk factor for coronary artery 
      disease (CAD). However, this is still a controversial issue. Recently, it was 
      reported that the level of tHcy is related to the extent and severity of CAD. 
      This study was designed to investigate the relationship between plasma tHcy 
      levels and the presence, extent, and severity of CAD. Three hundred and forty-one 
      patients who underwent coronary angiography were included in the study. Of these 
      patients, 195 had CAD and 146 had normal coronary arteries (control group). The 
      mean tHcy level was found to be higher in patients with significant CAD (16.4 +/- 
      7.4 micromol/L vs 13.2 +/- 3.6 micromol/L, P < 0.001). This group also had a 
      higher rate of hyperhomocysteinemia (HHcy) (22.6% vs 5.5%, P < 0.001). There were 
      positive relationships between tHcy levels and male gender (P = 0.03, r = 0.16), 
      smoking (P < 0.001, r = 0.19), hyperlipidemia (P = 0.006, r = 0.15), and 
      hypertension (P < 0.001, r = 0.20). Using regression analysis HHcy was determined 
      to be an independent risk factor for CAD (OR = 3.69, CI 95% 1.51-9.06, P = 
      0.004). However, HHcy was not an independent risk factor in patients with low 
      cardiovascular risk profiles. There was no relationship between the level of tHcy 
      and the severity, extent, and vessel scores of CAD. On the other hand, age and 
      diabetes mellitus were related with all scores of CAD. In conclusion, although 
      hyperhomocysteinemia is an independent risk factor for CAD in our region, it 
      appears to be unrelated to the extent and severity of the disease.
FAU - Bozkurt, Abdi
AU  - Bozkurt A
AD  - Department of Cardiology, School of Medicine, Cukurova University, Adana, Turkey.
FAU - Toyaksi, Hale
AU  - Toyaksi H
FAU - Acarturk, Esmeray
AU  - Acarturk E
FAU - Tuli, Abdullah
AU  - Tuli A
FAU - Cayli, Murat
AU  - Cayli M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Heart J
JT  - Japanese heart journal
JID - 0401175
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Case-Control Studies
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/diagnostic imaging/etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2003/06/27 05:00
MHDA- 2003/07/09 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2003/07/09 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - 10.1536/jhj.44.357 [doi]
PST - ppublish
SO  - Jpn Heart J. 2003 May;44(3):357-68. doi: 10.1536/jhj.44.357.