PMID- 12826211
OWN - NLM
STAT- MEDLINE
DCOM- 20040211
LR  - 20190713
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 35
IP  - 4
DP  - 2003 Jun
TI  - Monocyte chemoattractant protein-1 levels in bronchoalveolar lavage fluid of 
      lung-transplanted patients treated with tacrolimus as rescue treatment for 
      refractory acute rejection.
PG  - 1523-6
AB  - BACKGROUND: Cytokines are important mediators of the complex process of 
      extravasation and influx of peripheral mononuclear cells into a site of graft 
      injury, an action that may be affected by the immunosuppressive regimen. The aim 
      of this study was to compare the effect of different immunosuppressive regimens 
      on cytokine expression in the grafted lung. METHODS: We analyzed the cytokine 
      profiles in broncho-alveolar lavage fluid (BAL-F) from 18 lung transplanted 
      patients undergoing a shift from a cyclosporine- to a tacrolimus-based triple 
      therapy regimen due to refractory acute rejection. RESULTS: Three months after 
      the conversion to tacrolimus, BAL-F levels of interleukin 8 (IL8), IL18, IL12 and 
      IL10 were not significantly different than those measured before conversion. In 
      contrast, monocyte chemoattractant protein-1 (MCP-1) levels showed a significant 
      and sustained decrease in BAL-F during tacrolimus therapy. In addition the levels 
      of gamma interferon (IFN-gamma) in the BAL-F were decreased albeit not 
      significantly. CONCLUSIONS: These findings suggest that the clinical and 
      functional stabilization of patients observed after conversion to a tacrolimus 
      based regimen, may be due, at least in part, to the induced down-regulation of 
      MCP-1 production.
FAU - Meloni, F
AU  - Meloni F
AD  - Department of Haematological Pneumological and Cardiovascular Sciences, Divisions 
      of Pneumology and Cardiac Surgery, University of Pavia, IRCCS San Matteo, Pavia, 
      Italy.
FAU - Cascina, A
AU  - Cascina A
FAU - Paschetto, E
AU  - Paschetto E
FAU - Marone Bianco, A
AU  - Marone Bianco A
FAU - Morosini, M
AU  - Morosini M
FAU - Pellegrini, C
AU  - Pellegrini C
FAU - Fietta, A
AU  - Fietta A
FAU - Vitulo, P
AU  - Vitulo P
FAU - Pozzi, E
AU  - Pozzi E
FAU - Vigano, M
AU  - Vigano M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Chemokine CCL2)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Interleukins)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Acute Disease
MH  - Biopsy
MH  - Bronchoalveolar Lavage Fluid/*chemistry
MH  - Chemokine CCL2/*analysis
MH  - Drug Therapy, Combination
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Graft Rejection/*drug therapy/pathology
MH  - Heart-Lung Transplantation/*immunology
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Interleukins/analysis
MH  - Tacrolimus/*therapeutic use
EDAT- 2003/06/27 05:00
MHDA- 2004/02/12 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2004/02/12 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - S0041134503004767 [pii]
AID - 10.1016/s0041-1345(03)00476-7 [doi]
PST - ppublish
SO  - Transplant Proc. 2003 Jun;35(4):1523-6. doi: 10.1016/s0041-1345(03)00476-7.