PMID- 12826308
OWN - NLM
STAT- MEDLINE
DCOM- 20031203
LR  - 20190922
IS  - 0169-5002 (Print)
IS  - 0169-5002 (Linking)
VI  - 41
IP  - 1
DP  - 2003 Jul
TI  - K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal 
      smoke in China.
PG  - 21-7
AB  - Lung cancer mortality rate in nonsmoking women in Xuan Wei (XW) County is the 
      highest in China. The XW lung cancer rate is associated with exposure to coal 
      smoke, containing high concentrations of polycyclic aromatic hydrocarbons (PAHs), 
      in unvented homes. Here we investigated codon 12 K-ras mutations in lung tumors 
      or sputum samples from 102 XW lung cancer patients (41 nonsmoking women and 61 
      smoking men). In addition, we analyzed specimens from 50 lung cancer patients (14 
      nonsmoking women, 33 smoking men and three nonsmoking men), from Beijing and 
      Henan (B&H), where natural gas is the main domestic fuel. K-ras mutations were 
      found in nine women (21.9%) and 14 men (22.9%) from XW, with G to T transversions 
      accounting for 66.7 and 85.7%, respectively. Among B&H patients, one woman (7.1%) 
      and six men (16.7%) had K-ras mutations, with G to T transversions accounting for 
      66.7% of the mutations in the men. Therefore, the frequency and type of K-ras 
      mutations in XW nonsmoking women are similar to those of K-ras mutations found in 
      both XW and B&H smoking men. On the other hand, the mutation frequency in XW 
      women is higher than, although not statistically significant from, that in the 
      B&H nonsmoking women (P=0.28, two-sided Fisher's Exact Test). These results 
      suggest an association between exposure to coal smoke and the increased K-ras 
      mutation frequency in XW nonsmoking female lung cancer patients. They also 
      suggest that the mutagens and/or mechanisms of mutations in these nonsmoking 
      women are similar to those responsible for K-ras mutations in cigarette smoking 
      lung cancer patients, which are probably induced largely by chemicals such as 
      PAHs.
FAU - Keohavong, Phouthone
AU  - Keohavong P
AD  - Department of Environmental and Occupational Health, University of Pittsburgh, 
      3343 Forbes Avenue, Pittsburgh, PA 15260, USA. pho1@pitt.edu
FAU - Lan, Qin
AU  - Lan Q
FAU - Gao, Wei-Min
AU  - Gao WM
FAU - DeMarini, David M
AU  - DeMarini DM
FAU - Mass, Marc J
AU  - Mass MJ
FAU - Li, Xue-Ming
AU  - Li XM
FAU - Roop, Barbara C
AU  - Roop BC
FAU - Weissfeld, Joel
AU  - Weissfeld J
FAU - Tian, Defa
AU  - Tian D
FAU - Mumford, Judy L
AU  - Mumford JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - 0 (Coal)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Smoke)
SB  - IM
MH  - Adult
MH  - China
MH  - Coal
MH  - DNA, Neoplasm
MH  - Environmental Exposure
MH  - Female
MH  - *Genes, ras
MH  - Humans
MH  - Lung Neoplasms/etiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Mutation
MH  - Smoke
MH  - Smoking
EDAT- 2003/06/27 05:00
MHDA- 2003/12/04 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2003/12/04 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - S0169500203001259 [pii]
AID - 10.1016/s0169-5002(03)00125-9 [doi]
PST - ppublish
SO  - Lung Cancer. 2003 Jul;41(1):21-7. doi: 10.1016/s0169-5002(03)00125-9.