PMID- 12826372
OWN - NLM
STAT- MEDLINE
DCOM- 20040220
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 7
DP  - 2003 Jul
TI  - Associations between measles antibody levels and the protein structure of class 
      II human leukocyte antigens.
PG  - 696-707
AB  - In this study, we describe associations between variation in human leukocyte 
      antigen (HLA) DP and DQ amino acid sequences and low measles antibody levels 
      after measles immunization. We tested serum samples from 242 children for measles 
      immunoglobulin G antibodies. We performed class II HLA typing and examined 
      associations between DQ and DP exon 2 amino acid sequences and antibody levels. 
      No DP amino acid variants were associated with seronegativity. However, 11 DQA 
      and 6 DQB amino acid variants were associated with seronegativity (p<0.005). 
      These amino acid variants were highly correlated, and the significant DQA amino 
      acids were only found in alleles *0201, *0301, *0401, *0501, and *0601. Two of 
      the amino acids associated with measles seronegativity were located in predicted 
      binding pockets of the DQ molecule; one was present in the leader sequence. Among 
      the DQB alleles, all of the amino acid variants associated with seronegativity 
      were present only in the DQB*0201 allele. Two of the amino acids associated with 
      seronegativity were located in predicted binding pockets of the DQ molecule; two 
      were located in the leader sequence. Our data suggest that specific DQA and DQB 
      amino acid variations are associated with measles seronegativity after 
      vaccination.
FAU - St Sauver, Jennifer L
AU  - St Sauver JL
AD  - Department of Health Sciences Research, Mayo Clinic and Foundation, Mayo Vaccine 
      Research Group, Rochester, MN 55905, USA. stsauver.jennifer@mayo.edu
FAU - Schaid, Daniel J
AU  - Schaid DJ
FAU - Vierkant, Robert A
AU  - Vierkant RA
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Jacobsen, Steven J
AU  - Jacobsen SJ
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
GR  - AR 30582/AR/NIAMS NIH HHS/United States
GR  - N01-AI-45240/AI/NIAID NIH HHS/United States
GR  - R01-2AI33144/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Measles Vaccine)
SB  - IM
MH  - Adolescent
MH  - *Alleles
MH  - Amino Acid Sequence
MH  - Antibodies, Viral/*blood
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *Genes, MHC Class II
MH  - HLA-DP Antigens/*chemistry/genetics
MH  - HLA-DQ Antigens/*chemistry/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Measles Vaccine/*immunology
MH  - Measles virus/drug effects/genetics/*immunology
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
EDAT- 2003/06/27 05:00
MHDA- 2004/02/21 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2004/02/21 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - S0198885903000879 [pii]
AID - 10.1016/s0198-8859(03)00087-9 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Jul;64(7):696-707. doi: 10.1016/s0198-8859(03)00087-9.