PMID- 12826377
OWN - NLM
STAT- MEDLINE
DCOM- 20040220
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 7
DP  - 2003 Jul
TI  - MCP-1 promoter polymorphism in Spanish patients with rheumatoid arthritis.
PG  - 741-4
AB  - To investigate the possible role of the polymorphism located in the regulatory 
      region of monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility 
      to rheumatoid arthritis (RA), a total of 141 Spanish RA patients and 194 
      controls, previously typed for human leukocyte antigen DRB1* (HLA-DRB1*), were 
      genotyped for -2518 (A/G) MCP-1 gene polymorphism using polymerase chain 
      reaction-restriction fragment length polymorphism. No association between -2518 
      (A/G) MCP-1 polymorphism and susceptibility to RA was found. Nevertheless, when 
      patients and controls were stratified according to their HLA shared epitope (SE) 
      status, a significant increase in the frequency of genotype GG was found among SE 
      negative (SE-) patients with respect to both SE positive (SE+) patients and SE- 
      controls (16% versus 4% in SE+ patients, pFisher=0.04, odds ratio [OR]=4.4, 95% 
      confidence interval [95%CI]=1.03-21.48; and 4% in SE- controls, pFisher=0.02, 
      OR=4.13, 95%CI=1.10-15.72). In conclusion, MCP-1 polymorphism is slightly 
      associated with the susceptibility to RA in patients lacking the HLA SE.
FAU - Gonzalez-Escribano, Maria Francisca
AU  - Gonzalez-Escribano MF
AD  - Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Servicio 
      Andaluz de Salud, Sevilla, Spain.
FAU - Torres, Belen
AU  - Torres B
FAU - Aguilar, Francisco
AU  - Aguilar F
FAU - Rodriguez, Rosa
AU  - Rodriguez R
FAU - Garcia, Alicia
AU  - Garcia A
FAU - Valenzuela, Angel
AU  - Valenzuela A
FAU - Nunez-Roldan, Antonio
AU  - Nunez-Roldan A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics/immunology/physiopathology
MH  - Chemokine CCL2/*genetics
MH  - DNA/analysis
MH  - DNA Primers
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR Antigens
MH  - HLA-DRB1 Chains
MH  - Hispanic or Latino
MH  - Humans
MH  - Male
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Spain
EDAT- 2003/06/27 05:00
MHDA- 2004/02/21 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2004/02/21 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - S0198885903000909 [pii]
AID - 10.1016/s0198-8859(03)00090-9 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Jul;64(7):741-4. doi: 10.1016/s0198-8859(03)00090-9.