PMID- 12826378
OWN - NLM
STAT- MEDLINE
DCOM- 20040220
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 7
DP  - 2003 Jul
TI  - HLA-B27 subtypes determination in patients with ankylosing spondylitis from 
      Zulia, Venezuela.
PG  - 745-9
AB  - To perform an investigation regarding the distribution of the human leukocyte 
      antigen (HLA)-B27 subtypes in the Zulian population with ankylosing spondylitis 
      (AS), 48 unrelated Mestizos, HLA-B27 positive by serology, were studied using the 
      polymerase chain reaction-specific sequence oligonucleotides probe (PCR-SSOP) and 
      specific sequence primers (SSP) to analyze the polymorphism in exons 2 and 3 of 
      the HLA-B27 gene. Only two of eight HLA-B27 subtypes studied (B*2701-B*2708) were 
      found. The distribution of these alleles in the population of patients was: 
      B*2705, 68.8%, and B*2702, 31.2%. B*2705 subtype showed significant association 
      with patients being male. In the healthy controls, the most common subtype was 
      B*2708. These results were compared with frequencies reported in other Mestizo 
      and Spanish populations and showed significant differences, such as a high 
      frequency of B*2702. Such results show that HLA*B2705 and HLA*B2702 are the 
      subtypes most frequently associated with AS in our Mestizo population and suggest 
      a possible protector role for HLA*B2708, which was found only in the healthy 
      population.
FAU - Cipriani, Ana
AU  - Cipriani A
AD  - University of Zulia, Zulia, Venezuela.
FAU - Rivera, Sergio
AU  - Rivera S
FAU - Hassanhi, Manzur
AU  - Hassanhi M
FAU - Marquez, Georgina
AU  - Marquez G
FAU - Hernandez, Rosaura
AU  - Hernandez R
FAU - Villalobos, Cecilia
AU  - Villalobos C
FAU - Montiel, Milagros
AU  - Montiel M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (DNA Primers)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aging
MH  - Alleles
MH  - Black People
MH  - DNA Primers
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-B27 Antigen/analysis/classification/*genetics
MH  - Histocompatibility Antigens Class I
MH  - Humans
MH  - Indians, South American/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Sex Characteristics
MH  - Spondylitis, Ankylosing/epidemiology/*genetics
MH  - Uveitis, Anterior/epidemiology/genetics
MH  - Venezuela/epidemiology
MH  - White People
EDAT- 2003/06/27 05:00
MHDA- 2004/02/21 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2004/02/21 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - S0198885903000855 [pii]
AID - 10.1016/s0198-8859(03)00085-5 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Jul;64(7):745-9. doi: 10.1016/s0198-8859(03)00085-5.