PMID- 12826699
OWN - NLM
STAT- MEDLINE
DCOM- 20031215
LR  - 20191107
IS  - 0196-3635 (Print)
IS  - 0196-3635 (Linking)
VI  - 24
IP  - 4
DP  - 2003 Jul-Aug
TI  - Absolute polymorphic teratozoospermia in patients with oligo-asthenozoospermia is 
      associated with an elevated sperm aneuploidy rate.
PG  - 598-603
AB  - Infertile patients with abnormal sperm parameters have an increased sperm 
      aneuploidy rate, despite a normal blood karyotype. The evaluation of sperm 
      chromosome aberrations in patients with teratozoospermia only has shown a rate 
      similar to that found in patients exhibiting oligo-astheno-teratozoospermia, 
      which suggests that teratozoospermia is the critical parameter associated with 
      aneuploidy. However, it is not known which alteration of the sperm morphology is 
      associated with chromosome aberrations. The few cases reported so far have shown 
      an association with the presence of abnormal head morphology and particularly 
      with enlarged heads. We report the sperm aneuploidy rate of 3 patients with 
      oligo-asthenozoospermia who have absolute teratozoospermia (100% abnormal forms) 
      and a different percentage of sperm head abnormalities. Fourteen healthy men with 
      normozoospermia served as control subjects. Sperm aneuploidy and diploidy rates 
      were calculated by using triple-color fluorescence in situ hybridization (FISH) 
      for chromosomes 12, X, and Y, and double-color FISH was used for chromosomes 8 
      and 18. Patient K53, who had the highest number of spermatozoa with enlarged 
      heads (54.3%), also had the highest aneuploidy and diploidy rates. The other 2 
      patients, K56 and K61, had sperm aneuploidy and diploidy rates lower than those 
      of patient K53 but still well above the range found in normal men. Sperm 
      chromosome abnormalities were intermediate in patient K61 and lower in patient 
      K56, who had the lowest rate of spermatozoa with enlarged heads (18.9%). These 
      data add further evidence that patients with teratozoospermia have an increased 
      sperm aneuploidy rate and that this is particularly high in presence of an 
      elevated percentage of spermatozoa with enlarged heads. For this reason, germ 
      cells exhibiting this abnormality should not be used in in vitro fertilization 
      programs.
FAU - Vicari, Enzo
AU  - Vicari E
AD  - Section of Endocrinology, Andrology and Internal Medicine, Department of 
      Biomedical Sciences, and Master in Andrological and Human Reproduction Sciences, 
      University of Catania, Catania, Italy.
FAU - de Palma, Adele
AU  - de Palma A
FAU - Burrello, Nunziatina
AU  - Burrello N
FAU - Longo, Giusi
AU  - Longo G
FAU - Grazioso, Caterina
AU  - Grazioso C
FAU - Barone, Nunziata
AU  - Barone N
FAU - Zahi, Mohamed
AU  - Zahi M
FAU - D'Agata, Rosario
AU  - D'Agata R
FAU - Calogero, Aldo E
AU  - Calogero AE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Androl
JT  - Journal of andrology
JID - 8106453
SB  - IM
MH  - Adult
MH  - Aneuploidy
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 18
MH  - Chromosomes, Human, Pair 8
MH  - Chromosomes, Human, X
MH  - Chromosomes, Human, Y
MH  - Diploidy
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Oligospermia/*genetics/*pathology
MH  - Sperm Head/pathology
MH  - XYY Karyotype
EDAT- 2003/06/27 05:00
MHDA- 2003/12/16 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2003/12/16 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - 10.1002/j.1939-4640.2003.tb02711.x [doi]
PST - ppublish
SO  - J Androl. 2003 Jul-Aug;24(4):598-603. doi: 10.1002/j.1939-4640.2003.tb02711.x.