PMID- 12826739
OWN - NLM
STAT- MEDLINE
DCOM- 20031105
LR  - 20171101
IS  - 1420-8008 (Print)
IS  - 1420-8008 (Linking)
VI  - 16
IP  - 3
DP  - 2003
TI  - Inflammatory markers in matched plasma and cerebrospinal fluid from patients with 
      Alzheimer's disease.
PG  - 136-44
AB  - It has been suggested that a number of molecules associated with inflammation are 
      involved in the pathogenesis of Alzheimer's disease (AD). We measured the levels 
      of alpha(1)-antichymotrypsin (ACT), alpha(1)-antitrypsin (AAT), interleukin-6 
      (IL-6), monocyte chemoattractant protein-1 (MCP-1) and oxidised low-density 
      lipoprotein (oxLDL) in matched cerebrospinal fluid (CSF) and plasma of 141 
      patients with probable AD. We found a significant relationship between CSF and 
      plasma levels of ACT (r = 0.4, p < 0.001), IL-6 (r = 0.74, p < 0.001), MCP-1 (r = 
      0.71, p < 0.001), and a borderline relationship between CSF and plasma oxLDL (r = 
      0.22, p < 0.05). In addition, linear regression analysis revealed a positive 
      correlation between levels of CSF-ACT and oxLDL (p < 0.001), but an inverse 
      relation between levels of CSF ACT, CSF AAT and MCP-1 (p < 0.001). A significant 
      correlation was also found between levels of CSF ACT, oxLDL and the ratio of CSF 
      to serum albumin, which is used as a measure of the blood-brain barrier function. 
      Our data extend previous reports regarding the inflammatory markers in the plasma 
      and CSF of patients with AD and provide good evidence that levels of ACT, IL-6, 
      MCP-1 and oxLDL in plasma and CSF might be candidates as biomarkers for 
      monitoring the inflammatory process in AD.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Sun, Yong-Xin
AU  - Sun YX
AD  - Department of Medicine, Malmo University Hospital, Malmo, Sweden.
FAU - Minthon, L
AU  - Minthon L
FAU - Wallmark, A
AU  - Wallmark A
FAU - Warkentin, S
AU  - Warkentin S
FAU - Blennow, K
AU  - Blennow K
FAU - Janciauskiene, S
AU  - Janciauskiene S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Peptide Fragments)
RN  - 0 (alpha 1-Antichymotrypsin)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - Alleles
MH  - Alzheimer Disease/*blood/*cerebrospinal fluid/genetics/psychology
MH  - Amyloid beta-Peptides/blood/cerebrospinal fluid
MH  - Apolipoproteins E/genetics
MH  - Biomarkers/*blood/*cerebrospinal fluid
MH  - Blood-Brain Barrier
MH  - Chemokine CCL2/blood/cerebrospinal fluid
MH  - Cognition
MH  - Humans
MH  - Inflammation/*metabolism
MH  - Interleukin-6/blood/cerebrospinal fluid
MH  - Lipoproteins, LDL/blood/cerebrospinal fluid
MH  - Peptide Fragments/blood/cerebrospinal fluid
MH  - alpha 1-Antichymotrypsin/blood/cerebrospinal fluid
EDAT- 2003/06/27 05:00
MHDA- 2003/11/06 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/02/16 00:00 [accepted]
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2003/11/06 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - 71001 [pii]
AID - 10.1159/000071001 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2003;16(3):136-44. doi: 10.1159/000071001.