PMID- 12827640
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20061115
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 49
IP  - 4
DP  - 2003 Sep 15
TI  - How is firing activity of substantia nigra cells regulated? Relevance of 
      pattern-code in the basal ganglia.
PG  - 216-25
AB  - The current model of the basal ganglia (BG) assumes that neurons use a firing 
      rate renewal code for movement computing under normal and pathological 
      conditions. Here, we report nonrenewal firing (neuronal firing is influenced by 
      its own previous activity) in cells of the anesthetized rat's substantia nigra 
      (SN). Both compensatory (short interspike intervals (ISIs) are followed by long 
      ISIs and vice versa) and persistent (short and long ISIs cluster for long time 
      periods) nonrenewal activity was found in 52.6% and 33.8% of SN cells, 
      respectively. A compensatory pattern was found in 77.7% of DA cells, but in only 
      9.8% of GABA-cells. Conversely, a persistent pattern was observed in 74.6% of 
      GABAergic cells and in only 9.9% of DA cells. These findings indicate two types 
      of nonrenewal firing pattern codes specifically present in SN dopaminergic and 
      GABAergic neurons. Disruption of these patterns may play a role in the 
      pathophysiology of basal ganglia disorders such as Parkinson's disease and 
      dyskinesias.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Rodriguez, Manuel
AU  - Rodriguez M
AD  - Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, 
      Canary Islands, Spain. mrdiaz@ull.es
FAU - Pereda, Ernesto
AU  - Pereda E
FAU - Gonzalez, Julian
AU  - Gonzalez J
FAU - Abdala, Patricio
AU  - Abdala P
FAU - Obeso, Jose A
AU  - Obeso JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - *Action Potentials
MH  - Algorithms
MH  - Animals
MH  - Basal Ganglia/*physiology
MH  - Electrophysiology
MH  - Interneurons/physiology
MH  - Male
MH  - Neurons/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substantia Nigra/*physiology
MH  - gamma-Aminobutyric Acid
EDAT- 2003/06/27 05:00
MHDA- 2003/11/11 05:00
CRDT- 2003/06/27 05:00
PHST- 2003/06/27 05:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/06/27 05:00 [entrez]
AID - 10.1002/syn.10233 [doi]
PST - ppublish
SO  - Synapse. 2003 Sep 15;49(4):216-25. doi: 10.1002/syn.10233.