PMID- 12828562
OWN - NLM
STAT- MEDLINE
DCOM- 20030801
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 58
IP  - 1
DP  - 2003 Jul
TI  - Chemokine upregulation follows cytokine expression in chronic relapsing 
      experimental autoimmune encephalomyelitis.
PG  - 81-8
AB  - Chronic relapsing experimental autoimmune encephalomyelitis (ChREAE) is an 
      autoimmune disease of the central nervous system (CNS) induced by CNS myelin 
      components. In the early active stage, both ChREAE and multiple sclerosis (MS) 
      are characterized by the presence of perivascular inflammatory cuffs disseminated 
      in the CNS. There is growing evidence that chemoattractant cytokines (chemokines) 
      play an important role in this process. The main goal of the present study was to 
      analyse the hypothesis that chemokine expression in the CNS during autoimmune 
      inflammation is regulated by proinflammatory cytokines. To address this concept, 
      we analysed temporal relations between chemokine and cytokine expression during 
      ChREAE. Phasic upregulation of gene expression for chemokines T-cell activation 
      gene 3 (TCA-3)/CCL1, monocyte chemoattractant protein-1 (MCP-1)/CCL2, macrophage 
      inflammatory protein-1 alpha (MIP-1alpha)/CCL3, MIP-1beta/CCL4, regulated on 
      activation normal T cell expressed and secreted (RANTES)/CCL5 and MIP-2/CXCL2-3 
      as well as cytokines tumour necrosis factor-alpha (TNF-alpha), -beta, LT-beta, 
      interferon-gamma (IFN-gamma) and transforming growth factor-beta1 (TGF-beta1) in 
      the CNS was observed during attacks of ChREAE. Expression of cytokines TNF-beta 
      and LT-beta preceded, and the expression of TGF-beta1 followed chemokine 
      upregulation. Our results suggest that chemokine expression during CNS autoimmune 
      inflammation may be regulated by some proinflammatory cytokines.
FAU - Glabinski, A R
AU  - Glabinski AR
AD  - Department of Neurology, Medical University of Lodz, ul. Kopcinskiego, Lodz, 
      Poland. aglabinski@afazja.am.lodz.pl
FAU - Bielecki, B
AU  - Bielecki B
FAU - Ransohoff, R M
AU  - Ransohoff RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Chemokines/*biosynthesis
MH  - Chronic Disease
MH  - Cytokines/*biosynthesis
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology
MH  - Female
MH  - Mice
MH  - Spinal Cord/immunology
MH  - Spleen/immunology
MH  - Up-Regulation
EDAT- 2003/06/28 05:00
MHDA- 2003/08/02 05:00
CRDT- 2003/06/28 05:00
PHST- 2003/06/28 05:00 [pubmed]
PHST- 2003/08/02 05:00 [medline]
PHST- 2003/06/28 05:00 [entrez]
AID - 1285 [pii]
AID - 10.1046/j.1365-3083.2003.01285.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2003 Jul;58(1):81-8. doi: 10.1046/j.1365-3083.2003.01285.x.