PMID- 12831366
OWN - NLM
STAT- MEDLINE
DCOM- 20040713
LR  - 20191025
IS  - 1471-2598 (Print)
IS  - 1471-2598 (Linking)
VI  - 3
IP  - 4
DP  - 2003 Jul
TI  - Peptide immunotherapy for allergic disease.
PG  - 617-26
AB  - The only disease-modifying treatment available for IgE-mediated disease is 
      specific immunotherapy, but the retention of B cell epitopes in whole allergen 
      preparations confers a risk of IgE-mediated systemic reactions to their 
      administration. Compelling evidence for the central role of T cells in allergic 
      disease suggests that IgE-binding epitopes could be removed from such therapy, 
      improving safety without affecting efficacy. Short, allergen-derived peptides 
      lack the conformational determinants required for IgE crosslinking and are, 
      therefore, an attractive therapeutic possibility. However, human leukocyte 
      antigen (HLA) polymorphism means that T cell peptide epitopes present a huge 
      diversity, which makes the design of peptide-based vaccines problematic. Over the 
      past 10 years, advances in our understanding of epitope selection and major 
      histocompatibility complex (MHC)-peptide-T cell receptor interactions have taken 
      this therapy forward to early clinical trials with human volunteers.
FAU - Tarzi, Michael
AU  - Tarzi M
AD  - Allergy and Clinical Immunology, Faculty of Medicine, Imperial College London, 
      National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK. 
      m.tarzi@ic.ac.uk
FAU - Larche, Mark
AU  - Larche M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
RN  - 0 (Peptides)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Hypersensitivity/pathology/*therapy
MH  - *Immunotherapy
MH  - Peptides/*therapeutic use
RF  - 76
EDAT- 2003/07/02 05:00
MHDA- 2004/07/14 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2004/07/14 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - 10.1517/14712598.3.4.617 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2003 Jul;3(4):617-26. doi: 10.1517/14712598.3.4.617.