PMID- 12832819
OWN - NLM
STAT- MEDLINE
DCOM- 20030909
LR  - 20061115
IS  - 0289-0003 (Print)
IS  - 0289-0003 (Linking)
VI  - 20
IP  - 6
DP  - 2003 Jun
TI  - Synaptic mechanisms underlying pheromonal memory in vomeronasal system.
PG  - 687-95
AB  - When female mice are mated, they form a memory of the pheromonal signal of the 
      male with which they mated. Our research objective was to determine the neural 
      mechanisms underlying learning and memory by employing a convenient model of 
      pheromone-induced olfactory memory (pheromonal memory). Formation of pheromonal 
      memory depends on the association between mating and exposure to pheromones. 
      Synaptic plasticity involving this memory occurs in the accessory olfactory bulb 
      (AOB), depending on vaginocervical stimulation at mating. The vaginocervical 
      stimulation at mating reduces the dendrodendritic feedback inhibition of 
      principal neurons (mitral/tufted (MT) cells) in the AOB and enhances their cell 
      activity. The enhancement of activity induces on these plastic changes in 
      dendrodendritic synapses, which in turn enhance GABA-mediated inhibition of MT 
      cell activity. This "self-inhibition" of MT cells activity in response to 
      pheromonal signals of the partner can disrupt its signals at the AOB thereby 
      preventing the signals from reaching the central brain. The formation and 
      maintenance of pheromonal memory is based on this inhibition mechanism.
FAU - Ichikawa, Masumi
AU  - Ichikawa M
AD  - Laboratory of Cell Biology and Anatomy, Department of Basic Techniques and 
      Facilities, Tokyo Metropolitan Institute for Neuroscience. mich@tmin.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Zoolog Sci
JT  - Zoological science
JID - 8702287
RN  - 0 (Sex Attractants)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - Mice
MH  - Neuronal Plasticity/*physiology
MH  - Olfactory Bulb/cytology/*physiology
MH  - Sex Attractants/*pharmacology
MH  - Sexual Behavior, Animal
MH  - Vomeronasal Organ/*physiology
MH  - gamma-Aminobutyric Acid/pharmacology
RF  - 37
EDAT- 2003/07/02 05:00
MHDA- 2003/09/10 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/09/10 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - 10.2108/zsj.20.687 [doi]
PST - ppublish
SO  - Zoolog Sci. 2003 Jun;20(6):687-95. doi: 10.2108/zsj.20.687.