PMID- 12833107
OWN - NLM
STAT- MEDLINE
DCOM- 20030715
LR  - 20140603
VI  - 27
IP  - 6
DP  - 2003 Jun
TI  - Exchanging carbohydrates for monounsaturated fats in energy-restricted diets: 
      effects on metabolic profile and other cardiovascular risk factors.
PG  - 648-56
AB  - OBJECTIVE: To investigate whether improvements in cardiovascular risk factors, as 
      observed in energy-balance conditions after exchanging carbohydrates (CHO) for 
      monounsaturated (MUFA) fats, are also observed in energy-restricted conditions. 
      DESIGN: Longitudinal, clinical intervention study using two types of 
      energy-restricted diets (-30% of initial energy intake) with similar levels of 
      saturated and polyunsaturated fats: a high CHO diet (55% of energy from CHOs, 10% 
      from MUFAs) and a high MUFA diet (40% of energy from CHOs, 25% from MUFAs). 
      SUBJECTS: A total of 32 overweight subjects (nine males, 23 females, BMI: 26-45 
      kg/m(2)). MEASUREMENTS: Body weight, serum lipids, fasting plasma insulin and 
      phospholipid fatty acid composition of red blood cells were measured at baseline 
      and after 8 weeks. Various oxidative status parameters (plasma lipid 
      hydroperoxides, total plasma antioxidant capacity, plasma uric acid and vitamin 
      E) and serum-induced smooth muscular cell (SMC) proliferation were also measured 
      at these time points. RESULTS: Weight loss (1.1 kg/week over the first 4 weeks 
      and 6.7 kg at week 8) was not significantly affected by the diet composition. 
      Both diets reduced significantly total serum cholesterol, but the MUFA-rich diet 
      showed better effects on fasting serum triacylglycerol (TG) than the CHO-rich 
      diet: 1.18 vs 1.51 mmol/l for the MUFA-rich diet (after vs before, P<0.05) and 
      1.42 vs 1.62 for the CHO-rich diet. After 8 weeks, plasma vitamin E 
      concentrations were positively associated with the oleic acid level of red blood 
      cell phospholipids and showed opposite variations in both diets (increase with 
      the MUFA-rich diet and decrease with the CHO-rich diet). Relative changes in SMC 
      proliferation induced by sera were negatively associated with the ratio 
      oleic:linoleic acid of red blood cell phospholipids and were significantly higher 
      with the CHO-rich diet. CONCLUSIONS: The MUFA-rich diet showed better effects on 
      serum TG than the CHO-rich diet, even with energy restriction and weight loss. 
      The results suggest also a protective effect of oleic acid on oxidative stress 
      and SMC proliferation, two other important cardiovascular risk factors.
FAU - Colette, C
AU  - Colette C
AD  - Laboratory of Human Nutrition and Atherogenesis, University Institute of Clinical 
      Research, Montpellier, Cedex, France. colette@iurc1.iurc.montp.inserm.fr
FAU - Percheron, C
AU  - Percheron C
FAU - Pares-Herbute, N
AU  - Pares-Herbute N
FAU - Michel, F
AU  - Michel F
FAU - Pham, T-C
AU  - Pham TC
FAU - Brillant, L
AU  - Brillant L
FAU - Descomps, B
AU  - Descomps B
FAU - Monnier, L
AU  - Monnier L
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Int J Obes Relat Metab Disord
JT  - International journal of obesity and related metabolic disorders : journal of the 
      International Association for the Study of Obesity
JID - 9313169
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Cells, Cultured
MH  - Cholesterol, HDL/metabolism
MH  - Cholesterol, LDL/metabolism
MH  - Dietary Carbohydrates/*metabolism
MH  - Dietary Fats/*metabolism
MH  - Fatty Acids, Monounsaturated/*metabolism
MH  - Fatty Acids, Unsaturated/metabolism
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Longitudinal Studies
MH  - Male
MH  - Myocytes, Smooth Muscle/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Weight Loss/*physiology
EDAT- 2003/07/02 05:00
MHDA- 2003/07/16 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/07/16 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - 0802299 [pii]
AID - 10.1038/sj.ijo.0802299 [doi]
PST - ppublish
SO  - Int J Obes Relat Metab Disord. 2003 Jun;27(6):648-56. doi: 
      10.1038/sj.ijo.0802299.