PMID- 12833123
OWN - NLM
STAT- MEDLINE
DCOM- 20030812
LR  - 20220309
IS  - 0969-7128 (Print)
IS  - 0969-7128 (Linking)
VI  - 10
IP  - 14
DP  - 2003 Jul
TI  - Receptor targeting of adeno-associated virus vectors.
PG  - 1142-51
AB  - Adeno-associated virus (AAV) is a promising vector for human somatic gene 
      therapy. However, its broad host range is a disadvantage for in vivo gene 
      therapy, because it does not allow the selective tissue- or organ-restricted 
      transduction required to enhance the safety and efficiency of the gene transfer. 
      Therefore, increasing efforts are being made to target AAV-2-based vectors to 
      specific receptors. The studies summarized in this review show that it is 
      possible to target AAV-2 to a specific cell. So far, the most promising approach 
      is the genetic modification of the viral capsid. However, the currently available 
      AAV-2 targeting vectors need to be improved with regard to the elimination of the 
      wild-type AAV-2 tropism and the improvement of infectious titers. The creation of 
      highly efficient AAV-2 targeting vectors will also require a better understanding 
      of the transmembrane and intracellular processing of this virus.
FAU - Buning, H
AU  - Buning H
AD  - Genzentrum Ludwig-Maximilians-Universitat Munchen, Feodor-Lynen-Strasse 25, 81377 
      Munich, Germany.
FAU - Ried, M U
AU  - Ried MU
FAU - Perabo, L
AU  - Perabo L
FAU - Gerner, F M
AU  - Gerner FM
FAU - Huttner, N A
AU  - Huttner NA
FAU - Enssle, J
AU  - Enssle J
FAU - Hallek, M
AU  - Hallek M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Gene Ther
JT  - Gene therapy
JID - 9421525
RN  - 0 (Antibodies)
RN  - 0 (Capsid Proteins)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Antibodies/genetics
MH  - Capsid Proteins/genetics
MH  - Dependovirus/*genetics
MH  - Gene Targeting/*methods
MH  - Genetic Engineering
MH  - Genetic Therapy/*methods
MH  - Genetic Vectors/*administration & dosage/genetics
MH  - Genome, Viral
MH  - Humans
MH  - Ligands
MH  - Receptors, Cell Surface/*metabolism
MH  - Transduction, Genetic/methods
RF  - 86
EDAT- 2003/07/02 05:00
MHDA- 2003/08/13 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/08/13 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - 3301976 [pii]
AID - 10.1038/sj.gt.3301976 [doi]
PST - ppublish
SO  - Gene Ther. 2003 Jul;10(14):1142-51. doi: 10.1038/sj.gt.3301976.