PMID- 12834440
OWN - NLM
STAT- MEDLINE
DCOM- 20030904
LR  - 20190922
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 15
IP  - 8
DP  - 2003 Aug
TI  - Oxytocin, but not oxytocin receptor, is rRegulated by oestrogen receptor beta in 
      the female mouse hypothalamus.
PG  - 787-93
AB  - In the female rat, oestrogen receptor (ER) beta is colocalized with both 
      oxytocin- and vasopressin-producing neurones in the paraventricular nucleus of 
      the hypothalamus (PVN). In this study, we demonstrate that the same pattern of 
      colocalization between ERbeta and oxytocin exists in the female mouse. Because 
      this nucleus contains only a negligible quantity of ERalpha, it is likely that 
      the oestrogen-dependent regulation of oxytocin and vasopressin synthesis in the 
      PVN is mediated by ERbeta. Thus, we compared the effect of ovarian hormones on 
      oxytocin and vasopressin mRNA expression in the PVN of wild-type (WT) and ERbeta 
      knockout (betaERKO) mice. We also compared the effects of ovarian hormones on 
      oxytocin receptor (OTR) expression in the medial amygdala (MeA) and ventromedial 
      nucleus of the hypothalamus (VMN) in female WT and betaERKO mice. Ovariectomized 
      mice underwent long-term treatment with oestradiol or oil. Progesterone was given 
      concurrently on the final 7 days of treatment, and all mice were killed 48 h 
      after the final progesterone injection. In the PVN, hormone treatment increased 
      oxytocin mRNA expression in WT but not betaERKO females. These results suggest 
      that ERbeta is necessary for the regulation of the expression of oxytocin in the 
      PVN. Hormone treatment had no effect on vasopressin mRNA expression in the PVN, 
      but significantly increased OTR binding in both the VMN and the MeA in both 
      genotypes. Collectively, our data show region and peptide specific regulation by 
      ERalpha and ERbeta in the mouse hypothalamus.
FAU - Patisaul, H B
AU  - Patisaul HB
AD  - NSF Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30329, USA. 
      hbeaupr@emory.edu
FAU - Scordalakes, E M
AU  - Scordalakes EM
FAU - Young, L J
AU  - Young LJ
FAU - Rissman, E F
AU  - Rissman EF
LA  - eng
GR  - K02 MH01349/MH/NIMH NIH HHS/United States
GR  - R01 MH57759/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Oxytocin)
RN  - 11000-17-2 (Vasopressins)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Estrogen Receptor beta
MH  - Estrogens/pharmacology
MH  - Female
MH  - Gene Expression/drug effects/physiology
MH  - Hypothalamus, Anterior/*metabolism
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Ovariectomy
MH  - Oxytocin/genetics/*metabolism
MH  - Paraventricular Hypothalamic Nucleus/*metabolism
MH  - Progesterone/pharmacology
MH  - Receptors, Estrogen/genetics/*metabolism
MH  - Receptors, Oxytocin/*metabolism
MH  - Vasopressins/genetics/metabolism
EDAT- 2003/07/02 05:00
MHDA- 2003/09/05 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/09/05 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - 1061 [pii]
AID - 10.1046/j.1365-2826.2003.01061.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2003 Aug;15(8):787-93. doi: 10.1046/j.1365-2826.2003.01061.x.