PMID- 12834800
OWN - NLM
STAT- MEDLINE
DCOM- 20031029
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 79
IP  - 2
DP  - 2003 Jul
TI  - Hippocampal serotonergic damage induced by MDMA (ecstasy): effects on spatial 
      learning.
PG  - 281-7
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) use has been associated with a decline 
      in various aspects of mnemonic function in humans. We therefore postulated that 
      MDMA-induced damage of serotonergic nerve terminals would alter hippocampal 
      processing. Seven days following treatment with MDMA (2 x 20 mg/kg sc, given 12 h 
      apart), rat spatial learning and memory were tested utilizing the Morris water 
      maze (MWM). No statistical differences were found in MWM platform acquisition 
      latency or pathlength between controls and MDMA-treated animals. Probe trials 
      revealed significantly higher proximity score averages and significantly reduced 
      preference for the target quadrant in the MDMA-treated animals. MDMA treatment 
      resulted in significant reduction (34%) in hippocampal serotonin (5-HT) levels 14 
      days after initial treatment. The findings of this study demonstrate that 
      hippocampal serotonergic lesions induced by MDMA may be ostensibly linked to a 
      reference memory deficit in rats tested with the MWM.
FAU - Sprague, Jon E
AU  - Sprague JE
AD  - Department of Pharmaceutical and Biomedical Sciences, Raabe College of Pharmacy, 
      Ohio Northern University, Ada, OH 45810, USA. j-sprague@onu.edu
FAU - Preston, Amanda S
AU  - Preston AS
FAU - Leifheit, Michael
AU  - Leifheit M
FAU - Woodside, Brian
AU  - Woodside B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Memory/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/*pharmacology
MH  - Swimming
EDAT- 2003/07/02 05:00
MHDA- 2003/10/30 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/10/30 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - S0031938403000921 [pii]
AID - 10.1016/s0031-9384(03)00092-1 [doi]
PST - ppublish
SO  - Physiol Behav. 2003 Jul;79(2):281-7. doi: 10.1016/s0031-9384(03)00092-1.