PMID- 12834886
OWN - NLM
STAT- MEDLINE
DCOM- 20030902
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 977
IP  - 2
DP  - 2003 Jul 11
TI  - Calbindin D28K immunoreactive neurons in vomeronasal organ and their projections 
      to the accessory olfactory bulb in the rat.
PG  - 261-9
AB  - The vomeronasal system is a nasal chemosensory system involved in pheromone 
      detection. The chemosensory receptor neurons are located in the sensory 
      epithelium of the vomeronasal organ (VNO). Their axons terminate in the glomeruli 
      of the accessory olfactory bulb (AOB). In this study, we examined the expression 
      of calbindin D28k (CB) in the rat VNO and AOB. In the VNO, a subpopulation of 
      receptor neurons in the middle layer of the sensory epithelium was immunostained 
      with antibodies to CB. Their axons could be traced to terminate in a group of 
      glomeruli in the anterior half of the AOB glomerular layer. This group of 
      CB-immunostained glomeruli in the anterior half of the AOB included a few large 
      glomeruli close to the boundary between the anterior and posterior halves of the 
      AOB, and several small glomeruli scattered in the anterior region of the AOB 
      glomerular layer. The positions of the CB-immunostained glomeruli in the AOB, 
      especially those close to the anterior-posterior boundary, were similar in the 
      two bulbs and in different rats. No sex difference was found. A developmental 
      study showed that the CB-immunoreactive receptor neurons in the middle layer of 
      the VNO sensory epithelium and CB-immunoreactive glomeruli in the anterior AOB 
      were present on the 14th postnatal day and older. The distribution pattern of the 
      CB-immunostained receptor neurons and their localized projection suggest the 
      possibility that these neurons may express the same or functionally related 
      pheromone receptor genes.
FAU - Jia, Changping
AU  - Jia C
AD  - Department of Anatomy and Cell Biology, State University of New York Downstate 
      Medical Center, Brooklyn, NY 11203, USA.
FAU - Halpern, Mimi
AU  - Halpern M
LA  - eng
GR  - DC 02745/DC/NIDCD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Calb1 protein, rat)
RN  - 0 (Calbindin 1)
RN  - 0 (Calbindins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (S100 Calcium Binding Protein G)
RN  - EC 3.6.5.1 (GTP-Binding Protein alpha Subunit, Gi2)
RN  - EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gi-Go)
RN  - EC 3.6.5.1 (Gnai2 protein, rat)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Animals, Newborn
MH  - Calbindin 1
MH  - Calbindins
MH  - Female
MH  - GTP-Binding Protein alpha Subunit, Gi2
MH  - GTP-Binding Protein alpha Subunits, Gi-Go/metabolism
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Nasal Mucosa/metabolism
MH  - Neural Pathways/*metabolism
MH  - Neurons/metabolism
MH  - Olfactory Bulb/cytology/growth & development/*metabolism
MH  - Proto-Oncogene Proteins/metabolism
MH  - Rats
MH  - S100 Calcium Binding Protein G/*metabolism
MH  - Vomeronasal Organ/cytology/growth & development/innervation/*metabolism
EDAT- 2003/07/02 05:00
MHDA- 2003/09/03 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/09/03 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - S0006899303026933 [pii]
AID - 10.1016/s0006-8993(03)02693-3 [doi]
PST - ppublish
SO  - Brain Res. 2003 Jul 11;977(2):261-9. doi: 10.1016/s0006-8993(03)02693-3.