PMID- 12835016
OWN - NLM
STAT- MEDLINE
DCOM- 20030923
LR  - 20191107
IS  - 0304-3894 (Print)
IS  - 0304-3894 (Linking)
VI  - 100
IP  - 1-3
DP  - 2003 Jun 27
TI  - Solubilization of the neutral and charged forms of 2,4,6-trichlorophenol by 
      beta-cyclodextrin, methyl-beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin 
      in water.
PG  - 109-16
AB  - The solubilities of the neutral and charged forms of 2,4,6-trichlorophenol (TCP) 
      in beta-cyclodextrin (beta-CD) and two of its most used derivatives: 
      methyl-beta-cyclodextrin (MCD) and hydroxypropyl-beta-cyclodextrin (HPCD) 
      solutions were investigated. The three cyclodextrins were found to form 1:1 
      inclusion complexes. Binding constants estimated from an enhancement solubility 
      method revealed that the stability of the complexes was dependent on the polarity 
      of the compound and on the cyclodextrin used.In general, weaker binding constants 
      were observed for TCP with beta-CD than with HPCD or MCD. The solubilization 
      efficiencies towards TCP can be ranked in the following order: MCD > HPCD > 
      beta-CD. For all cyclodextrins, the stability constant of neutral TCP 
      (logK(ow)=3.85) was larger than that of charged TCP (logK(ow)=1.4).A 
      precipitation occurred in TCP/beta-CD solution (around 10 g/l beta-CD 
      concentration) at pH 3. However, this phenomenon is not observed for TCP/beta-CD 
      solution at pH 8.8.
FAU - Hanna, K
AU  - Hanna K
AD  - Laboratoire d'analyse environmental des procedes et des systemes industriels-INSA 
      de Lyon, 20, avenue Albert Einstein, 69621 Villeurbanne Cedex, France. 
      hanna@genserver.insa-lyon.fr
FAU - de Brauer, C
AU  - de Brauer C
FAU - Germain, P
AU  - Germain P
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Carcinogens)
RN  - 0 (Chlorophenols)
RN  - 0 (Cyclodextrins)
RN  - 0 (Mutagens)
RN  - 0 (Soil Pollutants)
RN  - 0 (beta-Cyclodextrins)
RN  - 0 (methyl-beta-cyclodextrin)
RN  - 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin)
RN  - JV039JZZ3A (betadex)
RN  - MHS8C5BAUZ (2,4,6-trichlorophenol)
SB  - IM
MH  - 2-Hydroxypropyl-beta-cyclodextrin
MH  - Carcinogens/*chemistry
MH  - Chemical Precipitation
MH  - Chlorophenols/*chemistry/isolation & purification
MH  - Cyclodextrins/*chemistry
MH  - Mutagens/*chemistry
MH  - Soil Pollutants/isolation & purification
MH  - Solubility
MH  - *beta-Cyclodextrins
EDAT- 2003/07/02 05:00
MHDA- 2003/09/25 05:00
CRDT- 2003/07/02 05:00
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/09/25 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
AID - S0304389403000682 [pii]
AID - 10.1016/s0304-3894(03)00068-2 [doi]
PST - ppublish
SO  - J Hazard Mater. 2003 Jun 27;100(1-3):109-16. doi: 10.1016/s0304-3894(03)00068-2.