PMID- 12836135
OWN - NLM
STAT- MEDLINE
DCOM- 20030924
LR  - 20200824
IS  - 0002-9297 (Print)
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 73
IP  - 2
DP  - 2003 Aug
TI  - Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are 
      strongly associated with obsessive-compulsive disorder.
PG  - 370-6
AB  - We evaluated a possible association between the brain-derived neurotrophic factor 
      (BDNF) gene and susceptibility to obsessive-compulsive disorder (OCD) by 
      genotyping a number of single-nucleotide polymorphisms (SNPs) and one 
      microsatellite marker from the extended BDNF locus in 164 triads with OCD. 
      Extensive background linkage disequilibrium was observed at this locus. 
      Single-locus transmission-distortion tests revealed significant evidence of 
      association with the disease for all the BDNF gene markers tested, including a 
      Val66Met variation affecting the sequence of the proBDNF protein. Analysis of 
      multi-SNP haplotypes provided similar results. Haplotype transmission comparisons 
      in this and previous studies point to a functionally distinct BDNF haplotype 
      uniquely marked by the rare Met66 allele, which is undertransmitted and likely 
      confers a protective effect in OCD and other psychiatric disorders.
FAU - Hall, Diana
AU  - Hall D
AD  - The Rockefeller University, Human Neurogenetics Laboratory, New York, NY, 10021, 
      USA.
FAU - Dhilla, Alefiya
AU  - Dhilla A
FAU - Charalambous, Anna
AU  - Charalambous A
FAU - Gogos, Joseph A
AU  - Gogos JA
FAU - Karayiorgou, Maria
AU  - Karayiorgou M
LA  - eng
GR  - M01 RR000102/RR/NCRR NIH HHS/United States
GR  - M01 RR00102/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20030627
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Precursors)
RN  - 0 (brain-derived neurotrophic factor precursor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Exons
MH  - Female
MH  - *Genetic Variation
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Introns
MH  - Linkage Disequilibrium
MH  - Male
MH  - Microsatellite Repeats
MH  - Obsessive-Compulsive Disorder/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Protein Precursors/genetics
PMC - PMC1180373
EDAT- 2003/07/02 05:00
MHDA- 2003/09/25 05:00
PMCR- 2004/02/01
CRDT- 2003/07/02 05:00
PHST- 2003/01/15 00:00 [received]
PHST- 2003/05/07 00:00 [accepted]
PHST- 2003/07/02 05:00 [pubmed]
PHST- 2003/09/25 05:00 [medline]
PHST- 2003/07/02 05:00 [entrez]
PHST- 2004/02/01 00:00 [pmc-release]
AID - S0002-9297(07)61924-7 [pii]
AID - 34877 [pii]
AID - 10.1086/377003 [doi]
PST - ppublish
SO  - Am J Hum Genet. 2003 Aug;73(2):370-6. doi: 10.1086/377003. Epub 2003 Jun 27.