PMID- 12836198
OWN - NLM
STAT- MEDLINE
DCOM- 20030731
LR  - 20071115
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 19
IP  - 1
DP  - 2003 Jan
TI  - [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: 
      "parasites"of the endocytosis pathway].
PG  - 100-6
AB  - The modulation of plasma membrane proteins involved in the communication with the 
      immune system is a general mechanism developed by viruses to escape the immune 
      response. Most of the studied examples have focused on viral proteins that 
      missort cellular proteins during their biosynthesis. However, an increasing 
      number of examples show that the down-modulation can also be achieved after 
      membrane delivery by targeting into the endocytic pathway. For both human 
      immunodeficiency virus (HIV) and Kaposi sarcoma-associated herpesvirus (KSHV), 
      the proteins required for this process are identified, Nef and K3/K5 
      respectively. The extensive studies in this field have shown that the mechanisms 
      by which these proteins "parasite" the endocytic pathway are completely 
      different. Nef directly interacts with components of the cellular machinery 
      involved in the vesicular transport between the endocytic compartments, mainly 
      the clathrin adaptor complexes (AP), inducing the misrouting of numerous cellular 
      proteins, including CD4, MHC-I, LIGHT, DC-SIGN, CD28 and MHC-II to the endosomal 
      degradation compartment or the trans Golgi-network. The K3 and K5 proteins from 
      KSHV act by inducing the ubiquitylation of the target proteins, such as CMH-I and 
      B7.2, triggering their internalization and subsequent degradation by the highly 
      conserved Tsg101/vps23 ubiquitin-dependent endosomal pathway. While these 
      findings show that the strategies used by viruses to target cellular proteins to 
      the endocytic pathway are extremely diverse, additional investigations are needed 
      for the complete understanding of the specific roles of Nef and K3/K5 in the 
      physiopathology of HIV and KSHV infections, respectively. In addition, these 
      viral factors represent valuable tools to study the pathway they are perturbing.
FAU - Benichou, Serge
AU  - Benichou S
AD  - Departement de Maladies Infectieuses, Inserm U.567, Cnrs UMR 8104, Institut 
      Cochin, Batiment Gustave Roussy, 27, rue du Faubourg Saint-Jacques, 75014 Paris, 
      France. benichou@cochin.inserm.fr
FAU - Benmerah, Alexandre
AU  - Benmerah A
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Proteines Nef du VIH et K3/K5 du virus associe au sarcome de Kaposi: des 
      "parasites" de la voie d'endocytose.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
RN  - 0 (Antigens, Surface)
RN  - 0 (Gene Products, nef)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (K3 protein, Kaposi's sarcoma-associated herpesvirus)
RN  - 0 (K5 protein, Human herpesvirus 8)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Ubiquitin)
RN  - 0 (Viral Proteins)
RN  - 0 (nef Gene Products, Human Immunodeficiency Virus)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Amino Acid Motifs
MH  - Animals
MH  - Antigens, Surface/metabolism
MH  - Cysteine Endopeptidases/metabolism
MH  - *Endocytosis
MH  - Gammaherpesvirinae/genetics/physiology
MH  - Gene Products, nef/chemistry/*physiology
MH  - Genes, nef
MH  - HIV Infections/immunology/virology
MH  - HIV-1/genetics/*physiology
MH  - Herpesvirus 8, Human/genetics/*physiology
MH  - Humans
MH  - Immediate-Early Proteins/chemistry/*physiology
MH  - Macromolecular Substances
MH  - Mice
MH  - Multienzyme Complexes/metabolism
MH  - Proteasome Endopeptidase Complex
MH  - Protein Processing, Post-Translational
MH  - Protein Transport/*physiology
MH  - Sarcoma, Kaposi/immunology/virology
MH  - Structure-Activity Relationship
MH  - Ubiquitin/metabolism
MH  - Viral Proteins/chemistry/*physiology
MH  - nef Gene Products, Human Immunodeficiency Virus
RF  - 35
EDAT- 2003/07/03 05:00
MHDA- 2003/08/02 05:00
CRDT- 2003/07/03 05:00
PHST- 2003/07/03 05:00 [pubmed]
PHST- 2003/08/02 05:00 [medline]
PHST- 2003/07/03 05:00 [entrez]
AID - 000763ar [pii]
AID - 10.1051/medsci/2003191100 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2003 Jan;19(1):100-6. doi: 10.1051/medsci/2003191100.